在英国进行的关于Bug Buster套装与非处方灭虱药治疗头虱的单盲、随机、对照研究。
Single blind, randomised, comparative study of the Bug Buster kit and over the counter pediculicide treatments against head lice in the United Kingdom.
作者信息
Hill N, Moor G, Cameron M M, Butlin A, Preston S, Williamson M S, Bass C
机构信息
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT.
出版信息
BMJ. 2005 Aug 13;331(7513):384-7. doi: 10.1136/bmj.38537.468623.E0. Epub 2005 Aug 5.
OBJECTIVE
To compare the effectiveness of the Bug Buster kit with a single treatment of over the counter pediculicides for eliminating head lice.
DESIGN
Single blind, multicentre, randomised, comparative clinical study.
SETTING
Four counties in England and one county in Scotland.
PARTICIPANTS
133 young people aged 2-15 years with head louse infestation: 56 were allocated to the Bug Buster kit and 70 to pediculicide treatment.
INTERVENTIONS
Home use of proprietary pediculicides (organophosphate or pyrethroid) or the Bug Buster kit.
MAIN OUTCOME MEASURE
Presence of head lice 2-4 days after end of treatment: day 5 for the pediculicides and day 15 for the Bug Buster kit.
RESULTS
The cure rate using the Bug Buster kit was significantly greater than that for the pediculicides (57% v 13%; relative risk 4.4, 95% confidence interval 2.3 to 8.5). Number needed to treat for the Bug Buster kit compared with the pediculicides was 2.26.
CONCLUSION
The Bug Buster kit was the most effective over the counter treatment for head louse infestation in the community when compared with pediculicides.
目的
比较“灭虱宝套装”与单次使用非处方灭虱药消除头虱的效果。
设计
单盲、多中心、随机、对照临床研究。
地点
英格兰的四个郡和苏格兰的一个郡。
参与者
133名2至15岁的头虱感染者：56人被分配使用“灭虱宝套装”，70人接受灭虱药治疗。
干预措施
在家使用专利灭虱药（有机磷或拟除虫菊酯）或“灭虱宝套装”。
主要观察指标
治疗结束后2至4天（灭虱药治疗为第5天，“灭虱宝套装”为第15天）头虱的存在情况。
结果
使用“灭虱宝套装”的治愈率显著高于使用灭虱药（57%对13%；相对危险度4.4，95%置信区间2.3至8.5）。与灭虱药相比，“灭虱宝套装”的需治人数为2.26。
结论
与灭虱药相比，“灭虱宝套装”是社区中治疗头虱感染最有效的非处方治疗方法。
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