Vrbíková J, Vondra K, Cibula D, Dvoráková K, Stanická S, Srámková D, Sindelka G, Hill M, Bendlová B, Skrha J
Institute of Endocrinology, Národní 8, Prague 1, 116 94 Czech Republic, Department of Obstetrics and Gynecology, Charles University, Apolinárská 28, Prague 2, 120 00 Czech Republic.
Hum Reprod. 2005 Dec;20(12):3328-32. doi: 10.1093/humrep/dei221. Epub 2005 Aug 5.
Sixty-nine young women with polycystic ovary syndrome (PCOS) [age 25.2+/- 4.7 years, with body mass index (BMI) 24.3 +/- 4.8 kg/m2; mean 6 SD] and 73 age-matched healthy females (BMI 22.3 +/- 3.3 kg/m2; mean +/- SD) were evaluated for the occurrence of features of metabolic syndrome according to the Adult Treatment Panel III.
Overt metabolic syndrome (the presence of three and more risk factors) was not more common in PCOS women (1/64, 1.6%) than in healthy controls (0/73, 0%). On the other hand, in nearly 50% of PCOS women isolated features of metabolic syndrome, most often a decrease in high-density lipoprotein (HDL) cholesterol, were found. Women with at least one feature of metabolic syndrome were, in comparison with women without any of these features, significantly more obese (P = 0.0001), with lower insulin sensitivity (P = 0.05). When comparing PCOS women according to the degree of insulin sensitivity, as determined by euglycaemic clamp, isolated features of metabolic syndrome were found in 8/17 women above the upper quartile, compared with 11/16 women below the lower quartile of insulin sensitivity (P = 0.20).
Overt metabolic syndrome is only rarely encountered in young Czech females affected by PCOS but its isolated features are relatively frequent, both in young PCOS patients and in age-matched control women.
根据成人治疗小组第三次报告，对69名患有多囊卵巢综合征（PCOS）的年轻女性[年龄25.2±4.7岁，体重指数（BMI）24.3±4.8kg/m²；均值±标准差]和73名年龄匹配的健康女性（BMI 22.3±3.3kg/m²；均值±标准差）进行代谢综合征特征发生情况的评估。
明显的代谢综合征（存在三个及以上危险因素）在PCOS女性中（1/64，1.6%）并不比健康对照者（0/73，0%）更常见。另一方面，在近50%的PCOS女性中发现了孤立的代谢综合征特征，最常见的是高密度脂蛋白（HDL）胆固醇降低。与没有任何这些特征的女性相比，有至少一项代谢综合征特征的女性明显更肥胖（P = 0.0001），胰岛素敏感性更低（P = 0.05）。根据通过正常血糖钳夹测定的胰岛素敏感性程度比较PCOS女性时，在上四分位数以上的17名女性中有8名发现了孤立的代谢综合征特征，而在胰岛素敏感性下四分位数以下的16名女性中有11名发现了该特征（P = 0.20）。
在受PCOS影响的年轻捷克女性中，明显的代谢综合征很少见，但其孤立特征相对常见，在年轻PCOS患者和年龄匹配的对照女性中均如此。
