Pourteymour Fard Tabrizi Fatemeh, Alipoor Beitollah, Mehrzad Sadaghiani Mahzad, Ostadrahimi Alireza, Malek Mahdavi Aida
Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
School of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran.
Int J Fertil Steril. 2013 Jan;6(4):244-9. Epub 2013 Mar 3.
Metabolic syndrome (MetS) is a clustering of factors known to increase the risk for cardiovascular disease (CVD) and diabetes mellitus. Polycystic ovary syndrome (PCOS), the most common endocrine disorder among reproductive-aged women, is also closely linked to MetS. Limited information is available pertaining to the prevalence of MetS in Iranian PCOS women; therefore this study assesses the frequency of MetS and its components among PCOS women from Tabriz, Iran.
In this cross-sectional study, we evaluated a total of 200 women with PCOS who referred to the only specialty and subspecialty gynecological center in Northwestern Iran. PCOS was diagnosed according to Rotterdam criteria. This study defined clinical and biochemical parameters for MetS by the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) criteria. Statistical analyses were performed with descriptive-analytical methods using SPSS software version 16.
MetS was identified in 39.5% of PCOS women. The frequencies of individual components of MetS among studied subjects were: high-density lipoprotein cholesterol level (HDL-C)<50 mg/ dL (99.5%), waist circumference(WC) ≥88cm (65%), triglycerides (TG) ≥150 mg/dL(98%), and blood pressure≥130/85 mmHg(34%).There were no fasting glucose concentrations≥110 mg/dL. The frequency of MetS increased with body mass index (BMI)as follows: normal (5.4%), overweight (41.5%) and obese (85.7%) women (p<0.0001).
The PCOS women in this study had a high frequency of MetS and its individual components, particularly decreased HDL-C and increased triglyceride levels. These data can useful for lifestyle modification programs.
代谢综合征（MetS）是一组已知会增加心血管疾病（CVD）和糖尿病风险的因素聚集。多囊卵巢综合征（PCOS）是育龄女性中最常见的内分泌疾病，也与MetS密切相关。关于伊朗PCOS女性中MetS患病率的信息有限；因此，本研究评估了伊朗大不里士PCOS女性中MetS及其组成成分的发生率。
在这项横断面研究中，我们评估了总共200名转诊至伊朗西北部唯一的专科和亚专科妇科中心的PCOS女性。PCOS根据鹿特丹标准进行诊断。本研究根据美国国家胆固醇教育计划成人治疗小组第三次报告（NCEP ATP III）标准定义了MetS的临床和生化参数。使用SPSS软件16版通过描述性分析方法进行统计分析。
在39.5%的PCOS女性中发现了MetS。研究对象中MetS各组成成分的发生率分别为：高密度脂蛋白胆固醇水平（HDL-C）<50mg/dL（99.5%）、腰围（WC）≥88cm（65%）、甘油三酯（TG）≥150mg/dL（98%）和血压≥130/85mmHg（34%）。空腹血糖浓度均未≥110mg/dL。MetS的发生率随体重指数（BMI）增加如下：正常（5.4%）、超重（41.5%）和肥胖（85.7%）女性（p<0.0001）。
本研究中的PCOS女性MetS及其各组成成分的发生率较高，尤其是HDL-C降低和甘油三酯水平升高。这些数据对生活方式改变计划可能有用。
