激素受体不能预测所有年龄组可手术乳腺癌女性的HER2/neu状态。

Hormone receptors do not predict the HER2/neu status in all age groups of women with an operable breast cancer.

作者信息

Huang H J, Neven P, Drijkoningen M, Paridaens R, Wildiers H, Van Limbergen E, Berteloot P, Amant F, Vergote I, Christiaens M R

机构信息

Division of Gynecologic Oncology in Department of Obstetrics and Gynecology, Levven University Hospital, Levven, Belgium.

出版信息

Ann Oncol. 2005 Nov;16(11):1755-61. doi: 10.1093/annonc/mdi364. Epub 2005 Aug 5.

DOI:10.1093/annonc/mdi364

PMID:16085689

Abstract

BACKGROUND

In breast cancer, there is an inverse relationship between HER2/neu overexpression and receptors for estrogen (ER) or progesterone (PR). Some clinical observations such as the age-related association between hormone receptors and tumour grade, which predicts HER2/neu overexpression, suggest an age-related relationship.

PATIENTS AND METHODS

Our study population consisted of 1362 consecutive women receiving primary surgery for non-metastatic invasive breast cancer. We compared the relationship between both hormone receptors and HER2/neu overexpression in different age groups taking other tumour characteristics into account.

RESULTS

In a multivariate model, considering the overall group, a negative ER, a negative PR and a high tumour grade were predictive for HER2/neu overexpression (P <0.001). Considering 246 women aged < or =45 years, the only predictor for HER2/neu overexpression in this age category was a high tumour grade (P = 0.003). Considering the 1116 women aged >45 years, ER (P = 0.001), PR (P = 0.001) and tumour grade (P <0.001) were associated with HER2/neu (P <0.001).

CONCLUSION

Our findings indicate that the association between ER, PR and HER2/neu overexpression varies with age. The hormone receptors are not an independent predictor for the HER2/neu status in young women while they are in elder patients.

摘要

背景

在乳腺癌中，HER2/neu过表达与雌激素（ER）或孕激素（PR）受体之间存在负相关关系。一些临床观察结果，如激素受体与肿瘤分级之间的年龄相关性（肿瘤分级可预测HER2/neu过表达），提示了一种与年龄相关的关系。

患者与方法

我们的研究人群包括1362例连续接受非转移性浸润性乳腺癌初次手术的女性。我们在考虑其他肿瘤特征的情况下，比较了不同年龄组中两种激素受体与HER2/neu过表达之间的关系。

结果

在多变量模型中，考虑总体人群时，ER阴性、PR阴性和高肿瘤分级可预测HER2/neu过表达（P<0.001）。考虑246例年龄≤45岁的女性，该年龄组中HER2/neu过表达的唯一预测因素是高肿瘤分级（P = 0.003）。考虑1116例年龄>45岁的女性，ER（P = 0.001）、PR（P = 0.001）和肿瘤分级（P<0.001）与HER2/neu相关（P<0.001）。