雌激素受体、孕激素受体及人表皮生长因子受体2/神经生长因子（ER、PR和HER-2/Neu）与乳腺浸润性导管癌其他预后因素的相关性
Correlation of ER, PR and HER-2/Neu with other Prognostic Factors in Infiltrating Ductal Carcinoma of Breast.
作者信息
Siadati Sepideh, Sharbatdaran Majid, Nikbakhsh Novin, Ghaemian Naser
机构信息
Dept. of Pathology, Babol University of Medical Sciences, Babol, Iran.
Dept. of Surgery, Babol University of Medical Sciences, Babol, Iran.
出版信息
Iran J Pathol. 2015 Summer;10(3):221-6.
BACKGROUND AND OBJECTIVES
Breast cancer is the most common malignancy among women in the world. The aim of this study was to assess estrogen receptor (ER), progesterone receptor (PR) and HER-2/neu of infiltrating ductal carcinoma (IDC) with tumor size, histologic grade, lymph node metastasis and age.
METHODS
This study was carried out on 300 tissue blocks of patients with IDC who underwent mastectomy from 2007 to 2011 in Shahid Beheshti Hospital, affiliated to Babol University of Medical Sciences, Babol, Iran. Data including age, tumor size, and histologic grade and lymph node status retrieved from pathology department.
RESULT
The mean age of the patients was 40.2±2.3 (ranged 19-82 years). ER and PR were positively correlated with each other ( P = 0.001) and they inversely correlated with HER-2/neu ( P =0.001). We observed correlation between ER and PR expression and low histologic grade ( P = 0.001) and HER-2/neu expression and high histologic grade ( P = 0.003). There was correlation between HER-2/neu expression and lymph node involvement ( P =0.03). None of these makers showed correlation with age and tumor size ( P > 0.05).
CONCLUSION
Our findings indicate the importance of ER, PR and HER-2/neu expression as prognostic factors for therapeutic decision.
背景与目的
乳腺癌是全球女性中最常见的恶性肿瘤。本研究的目的是评估浸润性导管癌（IDC）的雌激素受体（ER）、孕激素受体（PR）和HER-2/neu与肿瘤大小、组织学分级、淋巴结转移及年龄的关系。
方法
本研究对2007年至2011年在伊朗巴博勒医科大学附属的沙希德·贝赫什提医院接受乳房切除术的300例IDC患者的组织块进行研究。从病理科获取包括年龄、肿瘤大小、组织学分级和淋巴结状态的数据。
结果
患者的平均年龄为40.2±2.3岁（范围为19 - 82岁）。ER和PR呈正相关（P = 0.001），且它们与HER-2/neu呈负相关（P = 0.001）。我们观察到ER和PR表达与低组织学分级相关（P = 0.001），HER-2/neu表达与高组织学分级相关（P = 0.003）。HER-2/neu表达与淋巴结受累相关（P = 0.03）。这些标志物均与年龄和肿瘤大小无相关性（P > 0.05）。
结论
我们的研究结果表明ER、PR和HER-2/neu表达作为治疗决策的预后因素具有重要意义。
Zotero 插件