Häcker Georg, Kirschnek Susanne, Fischer Silke F
Institute for Medical Microbiology, Immunology and Hygiene, Technical University Munich, Trogerstr. 9, 81675 Munich, Germany.
Med Microbiol Immunol. 2006 Mar;195(1):11-9. doi: 10.1007/s00430-005-0239-4. Epub 2005 Aug 6.
Cell death by apoptosis is a common response of a human cell to many extrinsic stimuli. A cell's sensitivity to apoptotic triggers is affected by its activation and differentiation status. Bacteria are recognised by cellular receptors and elicit a multitude of signal transduction events that can, among other effects, alter the cell's response towards apoptotic stimuli. Many different bacteria and bacterial products have been recognised as agents that can act in this way and either induce or inhibit cell death. Besides these common and, as we argue, indirect activities, chlamydiae have been described to have a more specific capacity. These specialists of intracellular life can directly attack the host cell's apoptotic pathway. Here, we will attempt to structure the field of bacterial inhibition of apoptosis and discuss recent advancements in our knowledge of how chlamydiae interfere with the host cell's capacity to undergo apoptosis.
细胞凋亡所致的细胞死亡是人体细胞对许多外在刺激的常见反应。细胞对凋亡触发因素的敏感性受其激活和分化状态的影响。细菌被细胞受体识别，并引发众多信号转导事件，这些事件除其他作用外，还可改变细胞对凋亡刺激的反应。许多不同的细菌和细菌产物已被确认为能够以这种方式发挥作用、诱导或抑制细胞死亡的因子。除了这些常见的、我们认为是间接的作用外，衣原体还被描述具有更特殊的能力。这些细胞内生存的专家能够直接攻击宿主细胞的凋亡途径。在此，我们将尝试梳理细菌抑制凋亡领域的相关内容，并讨论我们在衣原体如何干扰宿主细胞凋亡能力方面的最新认识进展。
