Lesitevuo Jorma, Huikko Solja, Rautakorpi Ulla-Maija, Leistevuo Tiina, Honkanen Pekka O, Klaukka Timo, Mäkelä Marjukka, Palva Erkki, Roine Risto, Sarkkinen Hannu, Varonen Helena, Huovinen Pentti
Antimicrobial Research Laboratory, Department of Human Microbial Ecology and Inflammation, National Public Health Institute, Turku, Finland.
Scand J Infect Dis. 2005;37(6-7):465-70. doi: 10.1080/00365540510037975.
The objective was to study prescription practices of primary care physicians in prescribing antibiotics for community-acquired respiratory tract infections. Design was time series analysis and cross-sectional survey. The setting was 30 community primary health care centres. A case report form was completed for 3478 patient consultations treated by 198 office-based primary care physicians. Main outcome measures were: classification of diagnoses of respiratory tract infections made by each physician; number of antibiotic prescriptions related to these diagnoses; each physician's mean weekly number of antibiotic prescriptions during 6 months before and after the survey. Patients' risk (odds ratio: OR) to receive an antibiotic prescription from the high and medium prescribers was 5.81 (95% confidence interval [CI] 4.85-6.96) and 2.41 (95% CI 2.04-2.86), compared to low prescribers. High and medium prescribers made more diagnoses of otitis media (OR 2.07, 95% CI 1.70-2.53 and 1.85, 95% CI 1.51-2.26, respectively) and fewer diagnoses of unspecified upper respiratory tract infection (OR 0.32, 95% CI 0.26-0.38 and 0.57, 95% CI 0.48-0.68, respectively) than low prescribers. The rank of the prescription rate of high, medium and low prescriber groups remained the same for all diagnoses except pneumonia. In addition, the annual rank between high, medium and low prescriber groups remained stable; high group prescribed more antibiotics during the year than medium group, which prescribed more than low prescriber group.
目的是研究基层医疗医生针对社区获得性呼吸道感染开具抗生素的处方行为。设计采用时间序列分析和横断面调查。研究地点为30个社区基层医疗中心。为198名门诊基层医疗医生诊治的3478例患者会诊填写了病例报告表。主要观察指标为:每位医生对呼吸道感染的诊断分类;与这些诊断相关的抗生素处方数量;每位医生在调查前后6个月内的平均每周抗生素处方数量。与低处方量医生相比,高处方量和中处方量医生的患者接受抗生素处方的风险(比值比:OR)分别为5.81(95%置信区间[CI]4.85 - 6.96)和2.41(95%CI 2.04 - 2.86)。高处方量和中处方量医生诊断中耳炎的比例更高(OR分别为2.07,95%CI 1.70 - 2.53和1.85,95%CI 1.51 - 2.26),而诊断未明确的上呼吸道感染的比例更低(OR分别为0.32,95%CI 0.26 - 0.38和0.57,95%CI 0.48 - 0.68)。除肺炎外,高、中、低处方量医生组在所有诊断中的处方率排名保持不变。此外,高、中、低处方量医生组之间的年度排名保持稳定;高处方量组在一年中开具的抗生素比中处方量组多,中处方量组又比低处方量组多。