Lapière C M, Nusgens B V
Laboratoire de Dermatologie Expérimentale, CHU Sart Tilman, Université de Liège, Belgique.
Pathol Biol (Paris). 1992 Feb;40(2):133-8.
The dermis is a differentiated connective tissue whose mechanical properties originate in a network of polymeric macromolecules associated to a variety of glycoproteins and proteoglycans. Each macromolecule contains specific recognition domains allowing their self-association and binding to other macromolecules and to the cell membrane receptors, through. Cell function is regulated by the transfer of information resulting from contact with the polymeric network, as well as by cytokines and growth factors. The structure of the genes encoding the different macromolecules and their regulation sequences are largely known. Various connective tissue disorders are due to alterations of these genes.
真皮是一种分化的结缔组织，其机械特性源于与多种糖蛋白和蛋白聚糖相关的聚合大分子网络。每个大分子都包含特定的识别结构域，使其能够通过这些结构域进行自我缔合，并与其他大分子以及细胞膜受体结合。细胞功能受与聚合网络接触所产生的信息传递以及细胞因子和生长因子的调节。编码不同大分子的基因结构及其调控序列已基本明确。多种结缔组织疾病都归因于这些基因的改变。
