Yamaguchi M
Endocrinol Jpn. 1979 Oct;26(5):605-9. doi: 10.1507/endocrj1954.26.605.
The effect of calcitonin (CT) on Ca-ATPase activity in the plasma membrane fraction of rat liver was investigated. CT (80 MRC mU/100 g BW) administered subcutaneously to rats, caused a significant decrease in serum calcium, while increasing liver calcium. The administration of CT produced a rapid decrease of Ca-ATPase activity in the plasma membrane fraction of liver, whereas CT did not cause a significant alteration of p-nitrophenyl phosphatase activity. The maximal response of CT was obtained with 80 MRC mU/100 g BW. Meanwhile, the administration of imidazole (30 mg/100 g BW) which has a hypocalcemic effect, like CT, produced a significant increase in liver calcium and a corresponding fall in Ca-ATPase activity of the plasma membrane fraction. The reduction of Ca-ATPase activity produced by imidazole was significantly potentiated by the simultaneous administration of CT, and the rise in liver calcium was enhanced slightly. The present results suggest that the action of CT on liver calcium involves the decrease of Ca-ATPase activity in the plasma membrane of rat liver.
研究了降钙素（CT）对大鼠肝脏质膜部分钙 - ATP酶活性的影响。给大鼠皮下注射CT（80 MRC mU/100 g体重）后，血清钙显著降低，而肝脏钙含量增加。CT的给药使肝脏质膜部分的钙 - ATP酶活性迅速降低，而CT并未引起对硝基苯磷酸酶活性的显著改变。CT的最大反应在80 MRC mU/100 g体重时获得。同时，与CT一样具有降钙作用的咪唑（30 mg/100 g体重）给药后，肝脏钙含量显著增加，质膜部分的钙 - ATP酶活性相应下降。咪唑产生的钙 - ATP酶活性降低被同时给予的CT显著增强，肝脏钙含量的升高略有增强。目前的结果表明，CT对肝脏钙的作用涉及大鼠肝脏质膜中钙 - ATP酶活性的降低。
