Yamaguchi M
Endocrinol Jpn. 1980 Jun;27(3):273-6. doi: 10.1507/endocrj1954.27.273.
The effects of calcitonin (CT), epinephrine and glucagon on the plasma membrane Ca-ATPase activity and the calcium content in the liver were investigated 30 min after a single subcutaneous administration of hormones to rats. Ca-ATPase activity in the plasma membrane fraction was significantly decreased by CT (80 MRC mU/100 g BW), while it was not significantly lowered by insulin (100 mU/100 g BW), epinephrine (100 micrograms/100 g BW), glucagon (50 micrograms/100 g BW), or parathyroid hormone (25 U/100 g BW). The calcium content in the liver was markedly increased by CT, while it was not significantly elevated by epinephrine or glucagon. Meanwhile, the decrease of Ca-ATPase activity in the plasma membrane fraction produced by CT was significantly prevented by simultaneous administration of epinephrine or glucagon, and also the increase in liver calcium was noticeably interfered with. The present results suggests that the action of CT on liver calcium may differ from that of epinephrine or glucagon which causes an increase in cyclic AMP in the liver cells.
在给大鼠单次皮下注射激素30分钟后，研究了降钙素（CT）、肾上腺素和胰高血糖素对肝质膜Ca - ATP酶活性及肝脏钙含量的影响。CT（80 MRC mU/100 g体重）可使质膜部分的Ca - ATP酶活性显著降低，而胰岛素（100 mU/100 g体重）、肾上腺素（100微克/100 g体重）、胰高血糖素（50微克/100 g体重）或甲状旁腺激素（25 U/100 g体重）则未使其显著降低。CT可使肝脏钙含量显著增加，而肾上腺素或胰高血糖素则未使其显著升高。同时，同时给予肾上腺素或胰高血糖素可显著阻止CT所致的质膜部分Ca - ATP酶活性降低，并且肝脏钙的增加也受到明显干扰。目前的结果表明，CT对肝脏钙的作用可能不同于肾上腺素或胰高血糖素，后者可导致肝细胞中环磷酸腺苷增加。
