一种用于高通量核磁共振波谱学的八线圈高频探头设计。

An eight-coil high-frequency probehead design for high-throughput nuclear magnetic resonance spectroscopy.

作者信息

Wang H, Ciobanu L, Edison A S, Webb A G

机构信息

Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

出版信息

J Magn Reson. 2004 Oct;170(2):206-12. doi: 10.1016/j.jmr.2004.07.001.

DOI:10.1016/j.jmr.2004.07.001

PMID:15388082

Abstract

In order to increase the throughput of high-resolution nuclear magnetic resonance spectroscopy a multiple-coil probe, which enables the simultaneous analysis of eight different samples, was designed. The probe, consisting of eight identical solenoidal coils, was constructed for operation at 600 MHz. By using four receivers and radiofrequency switches, spectra from eight different chemical solutions were acquired in the time normally required for one. Two-dimensional COSY, gradient COSY, and TOCSY data have been acquired. Intercoil electrical isolation was between 25 and 45 dB, with signal cross-talk between approximately 1 and 5% measured by NMR. The spectral linewidths for the eight coils were between 3 and 6Hz for a single optimized shim setting.

摘要

为了提高高分辨率核磁共振波谱的通量，设计了一种多线圈探头，该探头能够同时分析八个不同的样品。该探头由八个相同的螺线管线圈组成，设计用于在600 MHz下运行。通过使用四个接收器和射频开关，在通常获取一个样品光谱所需的时间内，采集了八个不同化学溶液的光谱。已采集二维COSY、梯度COSY和TOCSY数据。线圈间的电隔离度在25至45 dB之间，通过核磁共振测量的信号串扰约为1%至5%。对于单个优化的匀场设置，八个线圈的谱线宽度在3至6 Hz之间。