Rupprecht T A, Pfister H W, Angele B, Kastenbauer S, Wilske B, Koedel U
Department of Neurology, Ludwig-Maximilians University, Munich, Germany.
Neurology. 2005 Aug 9;65(3):448-50. doi: 10.1212/01.wnl.0000171349.06645.79.
Using protein expression profiling, the authors identified an upregulation of the chemokine B lymphocyte chemoattractant (BLC) in the CSF of patients with neuroborreliosis but not in patients with noninflammatory and various other inflammatory neurologic diseases. This upregulation was confirmed by ELISA, showing increased BLC levels in every neuroborreliosis patient while being undetectable in patients with noninflammatory neurologic diseases. These results point to BLC as a putative additional diagnostic marker for neuroborreliosis.
通过蛋白质表达谱分析，作者发现神经莱姆病患者脑脊液中的趋化因子B淋巴细胞趋化因子（BLC）上调，而在非炎症性和其他各种炎症性神经疾病患者中则未上调。酶联免疫吸附测定（ELISA）证实了这种上调，结果显示每位神经莱姆病患者的BLC水平均升高，而非炎症性神经疾病患者中则检测不到。这些结果表明BLC可能是神经莱姆病的一种额外诊断标志物。
