Ménégon P, Sibon I, Pachai C, Orgogozo J M, Dousset V
Service de Neuroradiologie, Hôpital Pellegrin, CHU Bordeaux, France.
Neurology. 2005 Aug 9;65(3):475-7. doi: 10.1212/01.wnl.0000171348.55820.89.
The clinical diagnosis of Marchiafava-Bignami disease (MBD) can be difficult. Acute demyelination of the corpus callosum is characteristic of the disease. The authors report the use of MR diffusion-weighted imaging (DWI) in six cases of acute MBD. They show that apparent diffusion coefficient restriction of the corpus callosum and cortical lesions were associated with a higher mortality rate and more severe cognitive sequelae.
马奇亚法瓦-比尼亚米病（MBD）的临床诊断可能具有挑战性。胼胝体急性脱髓鞘是该疾病的特征。作者报告了6例急性MBD患者使用磁共振扩散加权成像（DWI）的情况。他们发现，胼胝体和皮质病变的表观扩散系数受限与较高的死亡率和更严重的认知后遗症相关。
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