Golub Elizabeth T, Purvis Lisa A, Sapun Marcella, Safaeian Mahboobeh, Beyrer Chris, Vlahov David, Strathdee Steffanie A
Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, Maryland 21205, USA.
AIDS Behav. 2005 Sep;9(3):301-9. doi: 10.1007/s10461-005-9004-3.
Injection drug users (IDUs) represent an important risk group for HIV infection. We assessed correlates of IDUs' willingness to participate (WTP) in HIV vaccine trials, and examined temporal changes in WTP. Participants were enrolled in ALIVE, a prospective study of HIV among IDUs in Baltimore; semi-annual visits include interviews and HIV serology. Questionnaires regarding WTP were administered in 1993-1994 and again in 2001-2002. Logistic regression was conducted to identify correlates of WTP. Wave 1 of the survey included 440 participants; Wave 2 included 582 participants (189 participated in both waves). WTP increased modestly over time (83.4 vs. 86.3%; p = 0.16). Monetary incentives were the strongest predictor of WTP (adjOR = 2.73; 95% CI: 1.72-4.35). High expectations of HIV treatment effectiveness did not predict WTP. In this cohort, WTP remained strong and modestly increased over the study period. These results should be considered in the planning of sampling and retention strategies for future vaccine trials.
注射吸毒者是感染艾滋病毒的一个重要风险群体。我们评估了注射吸毒者参与艾滋病毒疫苗试验意愿（WTP）的相关因素，并研究了WTP随时间的变化。参与者被纳入ALIVE研究，这是一项对巴尔的摩注射吸毒者中的艾滋病毒进行的前瞻性研究；每半年进行一次访视，包括访谈和艾滋病毒血清学检测。关于WTP的问卷分别在1993 - 1994年和2001 - 2002年进行了发放。进行逻辑回归以确定WTP的相关因素。调查的第一波包括440名参与者；第二波包括582名参与者（189名参与者两波都参加了）。随着时间的推移，WTP略有增加（83.4%对86.3%；p = 0.16）。金钱激励是WTP最强的预测因素（调整后的比值比 = 2.73；95%置信区间：1.72 - 4.35）。对艾滋病毒治疗效果的高期望并不能预测WTP。在这个队列中，WTP在研究期间一直很强且略有增加。在规划未来疫苗试验的抽样和保留策略时应考虑这些结果。
