School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada.
Vaccine. 2010 Feb 17;28(7):1663-7. doi: 10.1016/j.vaccine.2009.12.023. Epub 2009 Dec 29.
This cross-sectional study involving a cohort of injection drug users (IDU) examined the relationship between cognitive factors (HIV treatment optimism, self-efficacy and knowledge of vaccine trial concepts) as well as risk factors for seroconversion, and willingness to participate (WTP) in a preventive phase 3 HIV vaccine trial. Willingness to participate overall was 56%. In a multivariate analysis, for a 20-unit increase in a 100-point composite scale, self-efficacy was positively related to WTP (adjusted odds ratio [AOR]=1.95, 95% CI=1.40-2.70). HIV treatment optimism and knowledge of vaccine trial concepts were unrelated to WTP. Aboriginal ethnicity (AOR=3.47, 95% CI=1.68-7.18) and a higher educational level (>or=high school) (AOR=1.96, 95% CI=1.07-3.59) were positively related to WTP. This study provides information on WTP for an HIV vaccine trial. Limitations and future directions are also discussed.
这项横断面研究涉及一组注射吸毒者（IDU），考察了认知因素（HIV 治疗乐观、自我效能和疫苗试验概念知识）以及血清转化率的危险因素与参与（WTP）预防 3 期 HIV 疫苗试验之间的关系。总体而言，参与意愿为 56%。在多变量分析中，100 分复合量表每增加 20 个单位，自我效能与 WTP 呈正相关（调整后的优势比 [AOR]=1.95，95%CI=1.40-2.70）。HIV 治疗乐观和疫苗试验概念知识与 WTP 无关。原住民种族（AOR=3.47，95%CI=1.68-7.18）和较高的教育水平（>或=高中）（AOR=1.96，95%CI=1.07-3.59）与 WTP 呈正相关。本研究提供了有关 HIV 疫苗试验参与意愿的信息。还讨论了限制因素和未来方向。
