Sandgren Andreas, Albiger Barbara, Orihuela Carlos J, Tuomanen Elaine, Normark Staffan, Henriques-Normark Birgitta
Swedish Institute for Infectious Disease Control, Solna, Sweden.
J Infect Dis. 2005 Sep 1;192(5):791-800. doi: 10.1086/432513. Epub 2005 Jul 21.
Streptococcus pneumoniae isolates of serotypes 1, 4, 6B, 7F, 14, and 19F belonging to clonal types with known invasive disease potential in humans were used to infect C57BL/6 and BALB/c mice. Most isolates were able to colonize the nasopharynx for 7 days. One serotype 19F isolate of the clonal type ST162 had higher bacterial numbers than other isolates and clonal types of the same serotype. Serotype 4 clones caused the most-severe invasive disease, whereas serotype 1 clones caused low-level bacteremia without disease symptoms. BALB/c mice were more likely than C57BL/6 mice to develop meningitis. Disease kinetics varied significantly between clonal types. Although most induced a robust tumor necrosis factor response, some isolates of serotype 1 and 7F did not, suggesting that invasive disease caused by different clonal types may result in different degrees of host response. Capsular serotype, other clonal properties, and host factors are important for the development of pneumococcal disease.
属于在人类中具有已知侵袭性疾病潜力的克隆类型的1、4、6B、7F、14和19F血清型肺炎链球菌分离株被用于感染C57BL/6和BALB/c小鼠。大多数分离株能够在鼻咽部定植7天。克隆类型ST162的一株19F血清型分离株的细菌数量高于同一血清型的其他分离株和克隆类型。4血清型克隆引起最严重的侵袭性疾病，而1血清型克隆引起低水平菌血症但无疾病症状。BALB/c小鼠比C57BL/6小鼠更易发生脑膜炎。疾病动力学在克隆类型之间有显著差异。虽然大多数诱导了强烈的肿瘤坏死因子反应，但1血清型和7F血清型的一些分离株没有，这表明由不同克隆类型引起的侵袭性疾病可能导致不同程度的宿主反应。荚膜血清型、其他克隆特性和宿主因素对肺炎球菌疾病的发生发展很重要。
