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证据表明，在小鼠中，血清型 3 分支 II 谱系的肺炎链球菌分离株的毒力降低，定植能力增强。

Evidence of Reduced Virulence and Increased Colonization Among Pneumococcal Isolates of Serotype 3 Clade II Lineage in Mice.

机构信息

Pfizer Inc, Bacterial Vaccines and Technology, Pearl River, New York.

Pfizer Inc, Early Clinical Development, Collegeville, Pennsylvania.

出版信息

J Infect Dis. 2024 Jul 25;230(1):e182-e188. doi: 10.1093/infdis/jiae038.

DOI:10.1093/infdis/jiae038
PMID:39052735
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11272092/
Abstract

Recent phylogenetic profiling of pneumococcal serotype 3 (Pn3) isolates revealed a dynamic interplay among major lineages with the emergence and global spread of a variant termed clade II. The cause of Pn3 clade II dissemination along with epidemiological and clinical ramifications are currently unknown. Here, we sought to explore biological characteristics of dominant Pn3 clades in a mouse model of pneumococcal invasive disease and carriage. Carriage and virulence potential were strain dependent with marked differences among clades. We found that clinical isolates from Pn3 clade II are less virulent and less invasive in mice compared to clade I isolates. We also observed that clade II isolates are carried for longer and at higher bacterial densities in mice compared to clade I isolates. Taken together, our data suggest that the epidemiological success of Pn3 clade II could be related to alterations in the pathogen's ability to cause invasive disease and to establish a robust carriage episode.

摘要

最近对肺炎球菌血清型 3（Pn3）分离株的系统发育分析揭示了主要谱系之间的动态相互作用，出现了一种称为谱系 II 的变体，并在全球范围内传播。目前尚不清楚 Pn3 谱系 II 传播的原因及其对流行病学和临床的影响。在这里，我们试图在肺炎球菌侵袭性疾病和携带的小鼠模型中探索主要 Pn3 谱系的生物学特征。携带和毒力潜力取决于菌株，谱系之间存在显著差异。我们发现与谱系 I 分离株相比，来自 Pn3 谱系 II 的临床分离株在小鼠中的毒力和侵袭性较弱。我们还观察到与谱系 I 分离株相比，谱系 II 分离株在小鼠中携带的时间更长，细菌密度更高。总之，我们的数据表明，Pn3 谱系 II 的流行病学成功可能与病原体引起侵袭性疾病和建立稳健携带期的能力的改变有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5673/11272092/14314c8f66d5/jiae038f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5673/11272092/d5dc9c9c5eab/jiae038f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5673/11272092/5cb70d8c78c5/jiae038f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5673/11272092/973e850b6316/jiae038f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5673/11272092/14314c8f66d5/jiae038f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5673/11272092/d5dc9c9c5eab/jiae038f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5673/11272092/5cb70d8c78c5/jiae038f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5673/11272092/973e850b6316/jiae038f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5673/11272092/14314c8f66d5/jiae038f4.jpg

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