Amaral Maribel M, Coelho Leonardo R, Flores Rosania P, Souza Raquel R, Silva-Carvalho Maria C, Teixeira Lenise A, Ferreira-Carvalho Bernadete T, Figueiredo Agnes M S
Institute of Microbiology Professor Paulo de Goes, Federal University of Rio de Janeiro, Brazil.
J Infect Dis. 2005 Sep 1;192(5):801-10. doi: 10.1086/432515. Epub 2005 Jul 22.
Methicillin-resistant Staphylococcus aureus (MRSA) has emerged as a therapeutic problem. In the present study, the molecular characterization by pulsed-field gel electrophoresis of MRSA isolates collected from a university hospital revealed that the predominant variant of the Brazilian epidemic clonal complex (BECC) was responsible for the increase in the incidence of MRSA strains, which reached 28% in 1998. It was verified that this predominant variant of the BECC displayed an enhanced ability to produce biofilm on inert polystyrene surfaces and to adhere to and invade epithelial airway cells. These results indicate that MRSA strains belonging to the BECC have evolved advantageous properties that might play a role in their predominance as international nosocomial pathogens.
耐甲氧西林金黄色葡萄球菌（MRSA）已成为一个治疗难题。在本研究中，通过脉冲场凝胶电泳对从一家大学医院收集的MRSA分离株进行分子特征分析，结果显示巴西流行克隆复合体（BECC）的主要变体导致了MRSA菌株发病率的上升，1998年该发病率达到了28%。研究证实，BECC的这种主要变体在惰性聚苯乙烯表面产生生物膜以及黏附并侵袭气道上皮细胞的能力增强。这些结果表明，属于BECC的MRSA菌株已进化出有利特性，这些特性可能在它们作为国际医院感染病原体的优势地位中发挥作用。
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