Potter D D, Pickles C D, Roberts R C, Rugg M D
Department of Psychology, University of St. Andrews, U.K.
Psychophysiology. 1992 Jan;29(1):29-37. doi: 10.1111/j.1469-8986.1992.tb02007.x.
Event-related potentials (ERPs) were recorded during a task requiring continuous recognition memory for visually-presented words. Twelve subjects each performed the task twice, once following the administration of scopolamine, and once after receiving a saline placebo. In the placebo condition, correctly detected "old" words (i.e., words that had been presented once before during the task) evoked more positive-going ERPs than did "new" words. Scopolamine caused a substantial impairment in task performance, but did not reduce the size of these old-word/new-word ERP differences. It is concluded that old/new ERP effects are unlikely to reflect cholinergically-mediated neural activity underlying normal recognition memory.
在一项需要对视觉呈现的单词进行连续再认记忆的任务中记录了事件相关电位（ERP）。12名受试者每人执行该任务两次，一次在服用东莨菪碱后，一次在接受生理盐水安慰剂后。在安慰剂条件下，正确检测到的“旧”单词（即在任务期间之前曾出现过一次的单词）比“新”单词诱发的ERP正向波幅更大。东莨菪碱导致任务表现出现显著损害，但并未减小这些旧词/新词ERP差异的幅度。得出的结论是，旧/新ERP效应不太可能反映正常再认记忆背后由胆碱能介导的神经活动。
