Rubenstein J H, Davis J, Marrero J A, Inadomi J M
The Division of Gastroenterology, University of Michigan Medical Center, Ann Arbor, MI, USA.
Aliment Pharmacol Ther. 2005 Aug 1;22(3):267-71. doi: 10.1111/j.1365-2036.2005.02544.x.
Obesity is a risk factor for adenocarcinomas of the oesophagus and gastric cardia. Diabetes mellitus might mediate that association.
To estimate the risk of diabetes mellitus on the development of adenocarcinoma of distal oesophagus and gastric cardia beyond that of gastro-oesophageal reflux disease.
A case-control study was performed using a national administrative database of the Veterans Administration.
A total of 311 cases of cancer and 10,154 controls were identified. Gender, age, and race were risks for cancer. Diabetes was diagnosed in 36% of cases, and 32% of controls (P = 0.15). Diabetic complications were diagnosed in 14% of cases and 13% of controls (P = 0.60). Multiple logistic regression confirmed the absence of an association between cancer and diabetes (odds ratio 1.1, 95% confidence interval 0.8-1.5) or diabetic complications (odds ratio 0.8, 95% confidence interval 0.6-1.3), adjusting for age, gender, and race.
Within the limitations of this case-control study, there is no evidence of an association between diabetes and adenocarcinoma of the oesophagus or gastric cardia among US veterans with gastro-oesophageal reflux disease.
肥胖是食管癌和贲门腺癌的危险因素。糖尿病可能介导这种关联。
评估糖尿病在胃食管反流病之外对远端食管癌和贲门腺癌发生风险的影响。
利用退伍军人管理局的全国行政数据库进行了一项病例对照研究。
共识别出311例癌症病例和10154例对照。性别、年龄和种族是患癌风险因素。36%的病例和32%的对照被诊断患有糖尿病（P = 0.15）。14%的病例和13%的对照被诊断患有糖尿病并发症（P = 0.60）。多因素逻辑回归分析在对年龄、性别和种族进行校正后，证实癌症与糖尿病（比值比1.1，95%置信区间0.8 - 1.5）或糖尿病并发症（比值比0.8，95%置信区间0.6 - 1.3）之间不存在关联。
在本病例对照研究的局限性范围内，没有证据表明在美国患有胃食管反流病的退伍军人中，糖尿病与食管癌或贲门腺癌之间存在关联。
