Flueckiger F, Ebner F, Poschauko H, Tamussino K, Einspieler R, Ranner G
Department of Radiology, University of Graz, Austria.
Radiology. 1992 Jul;184(1):89-93. doi: 10.1148/radiology.184.1.1609108.
Serial magnetic resonance imaging studies were performed in 28 patients undergoing primary radiation therapy for invasive cervical cancer. T2-weighted spin-echo pulse sequences with long repetition times (2,500 msec) and echo times (30-100 msec) were used at a field strength of 1.5 T. Eighteen tumors responded promptly to radiation therapy with a volume reduction and significant decrease of signal intensity in the early posttreatment phase (1-3 months) and with total tumor regression at 1-6 months (immediate responders). At 6 months seven tumors were visible as residual tumors with declining signal intensity; all seven of these tumors had resolved at 9 months (delayed responders). Thus, a delayed response with residual tumor at 6 months was still compatible with subsequent clinical cure. The tumors showed progression and no marked change in signal intensity (nonresponders). Primary tumors with a volume of more than 50 cm3 were more likely to have no or delayed response. An early (2-3 months) and significant decrease in the signal intensity and volume of a tumor indicates a favorable response. Large primary tumors may show a delayed response.
对28例接受浸润性宫颈癌原发性放射治疗的患者进行了系列磁共振成像研究。在1.5T的场强下，使用具有长重复时间（2500毫秒）和回波时间（30 - 100毫秒）的T2加权自旋回波脉冲序列。18例肿瘤对放射治疗反应迅速，在治疗后早期（1 - 3个月）体积缩小且信号强度显著降低，在1 - 6个月时肿瘤完全消退（即时反应者）。6个月时，有7个肿瘤表现为残留肿瘤，信号强度下降；所有这7个肿瘤在9个月时均消失（延迟反应者）。因此，6个月时出现残留肿瘤的延迟反应仍与随后的临床治愈相符。肿瘤表现为进展且信号强度无明显变化（无反应者）。体积超过50立方厘米的原发性肿瘤更有可能无反应或出现延迟反应。肿瘤信号强度和体积在早期（2 - 3个月）显著降低表明反应良好。大的原发性肿瘤可能表现出延迟反应。
