Blouin Karine, Després Jean-Pierre, Couillard Charles, Tremblay Angelo, Prud'homme Denis, Bouchard Claude, Tchernof André
Molecular Endocrinology and Oncology Research Center, Laval University Medical Research Center, Quebec, Canada G1V 4G2.
Metabolism. 2005 Aug;54(8):1034-40. doi: 10.1016/j.metabol.2005.03.006.
Plasma dehydroepiandrosterone sulfate (DHEA-S) and testosterone levels both decline with age in healthy men. Features of the metabolic syndrome also show age-related deteriorations. We examined the relative contribution of age and declining androgen levels to features of the metabolic syndrome in men. In a sample of 130 nonsmoking men from the Quebec Family Study, we tested the hypothesis that age-related decreases in DHEA-S and testosterone levels would explain most of the variance in alterations of the metabolic profile associated with aging. As expected, we found that plasma DHEA-S and testosterone levels were negatively associated with age. Significant negative correlations were found between androgen levels and adiposity measures, body fat distribution, and metabolic risk variables. Statistical control for age eliminated correlations with DHEA-S, whereas age-adjusted associations between testosterone and most adiposity and metabolic variables remained significant. The percentage frequency of men characterized by 3 or more features of the metabolic syndrome increased with decreasing testosterone (8.9%-44.2%, chi2 = 15.89, P < .0005 ) and DHEA-S levels (8.9%-41.5%, chi2 = 13.02, P < .005). Logistic regression analyses showed that men in the upper tertile of testosterone levels had a lower risk of being characterized by 3 or more features of the metabolic syndrome (odds ratio = 0.24, P < .04) independent of age, whereas tertiles of DHEA-S levels were not related to the metabolic syndrome independent of age. In conclusion, results suggest that age per se is an important correlate of the associations between DHEA-S and metabolic variables, whereas the association of plasma testosterone levels to features of the metabolic syndrome appears to be independent of age.
在健康男性中，血浆硫酸脱氢表雄酮（DHEA-S）和睾酮水平均会随着年龄增长而下降。代谢综合征的特征也呈现出与年龄相关的恶化。我们研究了年龄和雄激素水平下降对男性代谢综合征特征的相对影响。在魁北克家庭研究的130名不吸烟男性样本中，我们检验了以下假设：DHEA-S和睾酮水平与年龄相关的下降可以解释与衰老相关的代谢谱改变中的大部分变异。正如预期的那样，我们发现血浆DHEA-S和睾酮水平与年龄呈负相关。雄激素水平与肥胖指标、体脂分布和代谢风险变量之间存在显著的负相关。对年龄进行统计控制消除了与DHEA-S的相关性，而睾酮与大多数肥胖和代谢变量之间经年龄调整后的关联仍然显著。具有3种或更多代谢综合征特征的男性百分比频率随着睾酮水平降低（8.9%-44.2%，卡方=15.89，P<.0005）和DHEA-S水平降低（8.9%-41.5%，卡方=13.02，P<.005）而增加。逻辑回归分析表明，睾酮水平处于上三分位数的男性具有3种或更多代谢综合征特征的风险较低（优势比=0.24，P<.04），且独立于年龄，而DHEA-S水平的三分位数与独立于年龄的代谢综合征无关。总之，结果表明，年龄本身是DHEA-S与代谢变量之间关联的重要相关因素，而血浆睾酮水平与代谢综合征特征之间的关联似乎独立于年龄。
