National Taiwan University Hospital, Taipei 100, Taiwan.
Eur J Clin Invest. 2010 Mar;40(3):220-5. doi: 10.1111/j.1365-2362.2009.02248.x. Epub 2009 Dec 30.
The previous studies regarding the association between endogenous dehydroepiandrosterone (DHEA) sulphate level and metabolic syndrome are inconsistent. This study aimed to investigate such relationship in elderly Taiwanese men.
Five hundred and eighty-five elderly Taiwanese men (mean age 68.7 +/- 8.3 years) were enrolled as the baseline cohort population in 2000. In addition to a questionnaire, body mass index (BMI), blood pressure, fasting blood glucose, lipids, albumin and serum DHEA-S levels were measured for each participant. Metabolic syndrome was based on the definition by the America Heart Association/National Heart Lung Blood Institute.
The prevalence of metabolic syndrome was 33.3%. Using multivariate logistic regression analyses with adjustments for age, smoking, alcohol, physical activities, albumin and BMI, there was a positive relationship between serum DHEA-S level and metabolic syndrome. The highest DHEA-S quartile group had increased risk for metabolic syndrome (odds ratio = 2.68, 95% confidence interval: 1.44-5.01, P < 0.01) compared with the lowest quartile group. The mean serum DHEA-S level increased with increasing number of metabolic syndrome components.
The prevalence of metabolic syndrome increases with elevated DHEA-S levels among elderly Taiwanese men. Thus, elevated serum DHEA-S level should be treated as an important risk factor for metabolic syndrome in elderly men.
先前关于内源性脱氢表雄酮（DHEA）硫酸盐水平与代谢综合征之间关联的研究结果并不一致。本研究旨在探讨老年台湾男性中存在这种关系。
2000 年，我们招募了 585 名老年台湾男性（平均年龄 68.7 +/- 8.3 岁）作为基线队列人群。除了问卷调查外，还测量了每位参与者的体重指数（BMI）、血压、空腹血糖、血脂、白蛋白和血清 DHEA-S 水平。代谢综合征的定义采用美国心脏协会/美国国立心肺血液研究所的标准。
代谢综合征的患病率为 33.3%。经过多变量逻辑回归分析，调整年龄、吸烟、饮酒、体力活动、白蛋白和 BMI 后，血清 DHEA-S 水平与代谢综合征之间存在正相关关系。与最低四分位组相比，DHEA-S 四分位最高组发生代谢综合征的风险增加（比值比=2.68，95%置信区间：1.44-5.01，P<0.01）。血清 DHEA-S 水平随代谢综合征成分数的增加而升高。
在老年台湾男性中，代谢综合征的患病率随 DHEA-S 水平升高而增加。因此，升高的血清 DHEA-S 水平应被视为老年男性代谢综合征的一个重要危险因素。
