吡嗪衍生物的研究。第四部分。某些6-烷氧基吡嗪-2-羧酸的合成与抑菌活性。
Investigations of pyrazine derivatives. Part IV. Synthesis and tuberculostatic activity of some 6-alkoxypyrazine-2-carboxylic acids.
作者信息
Foks H, Manowska W
出版信息
Pol J Pharmacol Pharm. 1976 Jan-Feb;28(1):49-53.
PMID:817274
Abstract
By alcoholysis of 2-cyjano-6-chloropyrazine corresponding 6-alkoxypyrazine-2-imidoesters (1,6,11,16) were formed, which were then transformed in esters and amides of 6-alkoxypyrazine-2-carboxylic acids. Some of these compounds show a weak tuberculostatic activity.
摘要
通过2-氰基-6-氯吡嗪的醇解反应生成了相应的6-烷氧基吡嗪-2-亚胺酸酯（1,6,11,16），然后将其转化为6-烷氧基吡嗪-2-羧酸的酯和酰胺。其中一些化合物表现出微弱的抗结核活性。
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