Kollamparambil Tanoj Gopalam, Jani Bhavdeep Rameshchandra, Aldouri Maadh, Soe Aung, Ducker David Anthony
Department of Neonatology, Medway Maritime Hospital, Gillingham, Kent, UK.
Acta Paediatr. 2005 Apr;94(4):499-501. doi: 10.1111/j.1651-2227.2005.tb01924.x.
C(w) is a low frequency red cell antigen that belongs to the Rh blood groups system. While not uncommon, anti-C(w) is rarely associated with clinically significant haemolytic disease of the newborn (HDN). When it does occur, it is often subclinical or of mild to moderate clinical severity. In the majority of pregnancies it is considered to be a naturally occurring antibody and has not been reported to cause hydrops fetalis or stillbirth. We report a case of anti-C(w) alloimmunization, which was associated with significant anaemia and hydrops fetalis, presenting at 35 wk gestation.
Pregnancies affected by anti-C(w) merit closer scrutiny. Consideration should be given to performing more frequent antenatal ultrasound assessments to detect hydrops fetalis. This may help to support the need for more invasive procedures (cordocentesis and intrauterine transfusions).
C(w)是一种属于Rh血型系统的低频红细胞抗原。虽然并不罕见，但抗C(w)很少与临床上显著的新生儿溶血病（HDN）相关。当它确实发生时，通常是亚临床的或临床严重程度为轻度至中度。在大多数妊娠中，它被认为是一种天然存在的抗体，尚未有导致胎儿水肿或死产的报道。我们报告一例抗C(w)同种免疫病例，该病例与严重贫血和胎儿水肿相关，于妊娠35周时出现。
受抗C(w)影响的妊娠值得更密切的监测。应考虑更频繁地进行产前超声评估以检测胎儿水肿。这可能有助于支持进行更多侵入性操作（脐血穿刺和宫内输血）的必要性。
