MacRury S M, Muir M, Hume R
Department of Medicine, Southern General Hospital, Glasgow.
Scott Med J. 1992 Apr;37(2):49-52. doi: 10.1177/003693309203700208.
Vitamin C (ascorbic acid) is an important anti-oxidant which may help to reduce free radical damage and atheroma formation in blood vessels. In a study in which a group of healthy volunteer subjects were followed up for 12 months and a group of patients with vascular disease taking Vitamin C supplements were followed for 23 months, we confirmed previous findings of seasonal variations in ascorbic acid and cholesterol and have shown an inverse relationship between leucocyte ascorbic acid and serum cholesterol levels. In healthy control subjects the increase in ascorbate and fall in cholesterol during the summer months was reversed when the weather changed to a more winter pattern, presumably due to dietary alterations. We found that ascorbic acid levels were lower in patients with peripheral vascular disease and that although normal ascorbic acid levels were achieved with Vitamin C supplementation, when supplements were stopped at the height of a normal summer, there was a fall in ascorbic acid and a rise in serum cholesterol to winter levels. Given these findings we suggest that patients with vascular disease should have Vitamin C supplements throughout the year.
维生素C（抗坏血酸）是一种重要的抗氧化剂，可能有助于减少自由基损伤和血管中动脉粥样硬化斑块的形成。在一项研究中，一组健康志愿者受试者被随访了12个月，另一组服用维生素C补充剂的血管疾病患者被随访了23个月，我们证实了先前关于抗坏血酸和胆固醇季节性变化的研究结果，并显示白细胞抗坏血酸与血清胆固醇水平之间存在负相关关系。在健康对照受试者中，夏季抗坏血酸增加和胆固醇下降的情况在天气转变为更具冬季特征时会逆转，这可能是由于饮食改变所致。我们发现外周血管疾病患者的抗坏血酸水平较低，并且尽管补充维生素C可使抗坏血酸水平恢复正常，但在正常夏季高峰期停止补充时，抗坏血酸水平会下降，血清胆固醇会上升至冬季水平。基于这些发现，我们建议血管疾病患者应全年补充维生素C。
