Spittle C R
Lancet. 1971 Dec 11;2(7737):1280-1. doi: 10.1016/s0140-6736(71)90601-5.
Following the chance observation that the author's serum-cholesterol could be varied between 140 and 230 mg. per 100 ml. by increasing the vitamin-C intake or by lowering it, a study was undertaken in healthy individuals and in patients with atherosclerosis. In healthy people under the age of 25, cholesterol levels tended to fall when 1 g. of vitamin C per day was added to an otherwise normal diet. In older people, no consistent pattern of serum-cholesterol change was seen, but in patients with a history of atherosclerosis, most of whom were on clofibrate and/or anticoagulants, the serum-cholesterol increased in the weeks when vitamin-C supplements increased in the weeks when vitamin-C supplements were given. It is suggested that this rise in serum-cholesterol is caused by mobilisation of the arterial cholesterol.
作者偶然发现，通过增加或降低维生素C的摄入量，其血清胆固醇水平可在每100毫升140至230毫克之间变化。据此，对健康个体和动脉粥样硬化患者进行了一项研究。在25岁以下的健康人群中，在正常饮食基础上每天添加1克维生素C时，胆固醇水平往往会下降。在老年人中，未观察到血清胆固醇变化的一致模式，但在有动脉粥样硬化病史的患者中，他们大多服用氯贝丁酯和/或抗凝剂，在给予维生素C补充剂的几周内，血清胆固醇升高。有人认为，血清胆固醇的这种升高是由动脉胆固醇的动员引起的。
