Tomasiuk Ryszard, Zubrzycki Igor Z, Wiacek Magdalena
Faculty of Medical and Health Sciences, Kazimierz Pułaski University of Technology and Humanities in Radom, Radom, Poland.
Department of Biometry and Mathematics, Botswana University of Agriculture and Natural Resources, Gaborone, Botswana.
Front Med (Lausanne). 2022 Oct 25;9:907067. doi: 10.3389/fmed.2022.907067. eCollection 2022.
Aging is an independent risk factor for the development of various diseases associated, among others, with detrimental blood levels of fat- and water-soluble vitamins. Thus, the objective of this study is to investigate age-related changes in blood levels of vitamin A, B12, C, D, and E. Subject serum vitamin levels were obtained from the combined National Health and Nutrition Examination Surveys (NHANES). NHANESIII and NHANES 1999-2000, 2001-2002, 2003-2004, and 2005-2006. The raw data set was stratified into five age groups G1- G5: 20 ≤ G1 < 30, 30 ≤ G2 < 40, 40 ≤ G3 < 50, 50 ≤ G4 < 60, and 60 ≤ G5 < 70 years of age. Age stratified data was cleaned using the modified Horn algorithm. The reference range for the vitamin level of a specific age group was defined as data between the first and third quartile of the subject defined by normal blood pressure and normal bone density. Age-dependent changes in serum/plasma vitamin levels were assessed using the bootstrap technique with 10,000 repeats and Bonferroni adjustment. There was a continuous increase in vitamin A, B12, D, and E levels in the blood. However, the vitamin C concentration remained virtually constant in all age groups. There was a lack of cross-correlations between lipid and water-soluble vitamin levels and blood pressure and bone health. The following reference levels for vitamin A, B12, C, D, and E in subjects older than 20 years of age were established: vitamin A: 1.32-2.8 mmol/L, vitamin B12: 257.94-498.33 pmol/L, vitamin C: 38.18-79.2 mmol/L, vitamin D: 76.33-199.36 nmol/L and vitamin E: 3.65-41.12 μmol/L.
衰老 是多种疾病发生的独立风险因素，这些疾病尤其与脂溶性和水溶性维生素的血液水平有害有关。因此，本研究的目的是调查维生素A、B12、C、D和E血液水平的年龄相关变化。受试者血清维生素水平来自综合的国家健康和营养检查调查（NHANES）。NHANES III以及NHANES 1999 - 2000、2001 - 2002、2003 - 2004和2005 - 2006的数据。原始数据集被分层为五个年龄组G1 - G5：20≤G1＜30、30≤G2＜40、40≤G3＜50、50≤G4＜60以及60≤G5＜70岁。使用改良的霍恩算法对年龄分层数据进行清理。特定年龄组维生素水平的参考范围定义为血压正常和骨密度正常的受试者第一和第三四分位数之间的数据。使用重复10000次的自助法技术和邦费罗尼校正评估血清/血浆维生素水平的年龄依赖性变化。血液中维生素A、B12、D和E的水平持续升高。然而，所有年龄组的维生素C浓度实际上保持恒定。脂溶性和水溶性维生素水平与血压和骨骼健康之间缺乏交叉相关性。确定了20岁以上受试者维生素A、B12、C、D和E的以下参考水平：维生素A：1.32 - 2.8 mmol/L，维生素B12：257.94 - 498.33 pmol/L，维生素C：38.18 - 79.2 mmol/L，维生素D：76.33 - 199.36 nmol/L，维生素E：3.65 - 41.12 μmol/L。
