使用口服避孕药治疗痤疮的激素疗法。

Hormonal therapy for acne using oral contraceptive pills.

作者信息

Harper Julie C

机构信息

Department of Dermatology, University of Alabama at Birmingham, Eye Foundation Hospital, 35294-0009, USA.

出版信息

Semin Cutan Med Surg. 2005 Jun;24(2):103-6. doi: 10.1016/j.sder.2005.03.003.

DOI:10.1016/j.sder.2005.03.003

PMID:16092798

Abstract

The etiology of acne vulgaris is multifactorial and complex. The four key factors involved in the development of acne include follicular plugging, inflammation, the presence and activity of Propionibacterium acnes, and sebum. Androgen hormones stimulate the sebaceous gland and promote sebum excretion. Therefore, therapies that have an overall antiandrogen effect, like combination oral contraceptive pills, may be useful in the management of acne vulgaris. Numerous combination oral contraceptive pills have been evaluated in the treatment of acne vulgaris and have been found to be effective. With a thorough understanding of their proper use and potential associated risks, these hormonal treatments may be prescribed safely and effectively to women with acne.

摘要

寻常痤疮的病因是多因素且复杂的。痤疮发生涉及的四个关键因素包括毛囊堵塞、炎症、痤疮丙酸杆菌的存在及活性，以及皮脂。雄激素刺激皮脂腺并促进皮脂分泌。因此，具有全面抗雄激素作用的疗法，如复方口服避孕药，可能对寻常痤疮的治疗有用。许多复方口服避孕药已被评估用于寻常痤疮的治疗，并被发现是有效的。在充分了解其正确用法和潜在相关风险后，这些激素治疗可安全有效地开给患有痤疮的女性。