Lam Charlene, Zaenglein Andrea L
Department of Dermatology, Penn State University/Hershey Medical Center, Hershey, Pennsylvania.
Department of Dermatology, Penn State University/Hershey Medical Center, Hershey, Pennsylvania; Department of Pediatrics, Penn State University/Hershey Medical Center, Hershey, Pennsylvania.
Clin Dermatol. 2014 Jul-Aug;32(4):502-15. doi: 10.1016/j.clindermatol.2014.05.002.
Acne vulgaris is an inflammatory disorder of the pilosebaceous follicle. It is well established that androgen hormones play a major role in sebum production and excretion, and are vital in the pathogenesis of acne. Isotretinoin notwithstanding, hormonal therapies such as combined oral contraceptives (COCs) and spironolactone are the only treatments that can affect sebum production and the androgen component of acne. Contraceptives are also used during isotretinoin therapy for pregnancy prevention. It is important for a dermatologist to be familiar with all the available methods of contraception to provide essential counseling to patients. The aim of this paper is to review the role of hormones in acne pathogenesis, discuss the use of hormonal therapies for acne, and detail various alternative contraceptive methods in relation to isotretinoin treatment and pregnancy prevention.
寻常痤疮是一种毛囊皮脂腺的炎症性疾病。雄激素在皮脂分泌和排泄中起主要作用，且在痤疮发病机制中至关重要，这一点已得到充分证实。尽管有异维A酸，但联合口服避孕药（COC）和螺内酯等激素疗法是仅有的能够影响皮脂分泌以及痤疮雄激素成分的治疗方法。在异维A酸治疗期间也会使用避孕药来预防怀孕。皮肤科医生熟悉所有可用的避孕方法，以便为患者提供必要的咨询，这一点很重要。本文旨在综述激素在痤疮发病机制中的作用，讨论痤疮激素疗法的应用，并详细介绍与异维A酸治疗和预防怀孕相关的各种替代避孕方法。
