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本文引用的文献

1
Human T cell leukemia virus type I Tax activates CD40 gene expression via the NF-kappa B pathway.人类I型T细胞白血病病毒Tax蛋白通过核因子κB信号通路激活CD40基因的表达。
Virology. 2005 Mar 1;333(1):145-58. doi: 10.1016/j.virol.2004.12.008.
2
Allogeneic stem-cell transplantation with reduced conditioning intensity as a novel immunotherapy and antiviral therapy for adult T-cell leukemia/lymphoma.采用降低预处理强度的异基因干细胞移植作为成人T细胞白血病/淋巴瘤的新型免疫疗法和抗病毒疗法。
Blood. 2005 May 15;105(10):4143-5. doi: 10.1182/blood-2004-11-4193. Epub 2005 Jan 21.
3
Clinicopathological features of cutaneous lesions of adult T-cell leukaemia/ lymphoma.成人T细胞白血病/淋巴瘤皮肤病变的临床病理特征
Br J Dermatol. 2005 Jan;152(1):76-81. doi: 10.1111/j.1365-2133.2004.06274.x.
4
Natural course of HTLV-1 carriers with monoclonal proliferation of T lymphocytes ("pre-ATL") in a 20-year follow-up study.一项20年随访研究中T淋巴细胞单克隆增殖的HTLV-1携带者（“前成人T细胞白血病/淋巴瘤”）的自然病程。
Blood. 2005 Jan 15;105(2):903-4. doi: 10.1182/blood-2004-06-2489.
5
HTLV-I Tax directly binds the Cdc20-associated anaphase-promoting complex and activates it ahead of schedule.人类嗜T淋巴细胞病毒I型（HTLV-I）Tax蛋白直接结合与细胞分裂周期蛋白20（Cdc20）相关的后期促进复合物，并使其提前激活。
Proc Natl Acad Sci U S A. 2005 Jan 4;102(1):63-8. doi: 10.1073/pnas.0406424101. Epub 2004 Dec 27.
6
In vivo and in vitro treatment of HTLV-1 and HTLV-2 infected cells with arsenic trioxide and interferon-alpha.用三氧化二砷和α干扰素对感染人嗜T淋巴细胞病毒1型和2型的细胞进行体内和体外治疗。
Leuk Lymphoma. 2005 Mar;46(3):347-55. doi: 10.1080/10428190400019966.
7
The HTLV-I Tax oncoprotein targets the retinoblastoma protein for proteasomal degradation.人嗜T淋巴细胞病毒I型（HTLV-I）的Tax癌蛋白将视网膜母细胞瘤蛋白作为蛋白酶体降解的靶点。
Oncogene. 2005 Jan 20;24(4):525-40. doi: 10.1038/sj.onc.1208105.
8
New therapeutic approaches for adult T-cell leukaemia.成人T细胞白血病的新治疗方法。
Lancet Oncol. 2004 Nov;5(11):664-72. doi: 10.1016/S1470-2045(04)01608-0.
9
Recognition of adult T-cell leukemia/lymphoma cells by CD4+ helper T lymphocytes specific for human T-cell leukemia virus type I envelope protein.识别针对I型人类T细胞白血病病毒包膜蛋白的CD4 +辅助性T淋巴细胞对成人T细胞白血病/淋巴瘤细胞的作用。
Clin Cancer Res. 2004 Oct 15;10(20):7053-62. doi: 10.1158/1078-0432.CCR-04-0897.
10
Quantitation of HTLV-I and II proviral load using real-time quantitative PCR with SYBR Green chemistry.采用SYBR Green化学法的实时定量PCR对HTLV-I和II前病毒载量进行定量分析。
J Clin Virol. 2004 Dec;31(4):275-82. doi: 10.1016/j.jcv.2004.05.016.

人类嗜T细胞病毒相关白血病/淋巴瘤

Human T cell lymphotropic virus-associated leukemia/lymphoma.

作者信息

Ratner Lee

机构信息

Division of Molecular Oncology, Washington University, 660 South Euclid Avenue, Saint Louis, MO 63110, USA.

出版信息

Curr Opin Oncol. 2005 Sep;17(5):469-73. doi: 10.1097/01.cco.0000174037.84903.fb.

DOI:10.1097/01.cco.0000174037.84903.fb
PMID:16093798
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2652726/
Abstract

PURPOSE OF REVIEW

This article summarizes the current pathophysiologic basis for human T cell lymphotropic virus-associated leukemia/lymphoma as well as past, present, and future therapeutic options.

RECENT FINDINGS

New studies have been published on allogeneic stem cell transplantation, arsenic trioxide, and bortezomib for this condition.

SUMMARY

Studies of the molecular biology of human T cell lymphotropic virus-1-induced T cell leukemia/lymphoma have defined a critical role for oncoprotein, Tax, and activation of nuclear factor kappaB transcription pathways, which have provided rational approaches to improved therapy for T cell leukemia/lymphoma as well as a model for other hematopoietic malignancies characterized by nuclear factor kappaB activation.

摘要

综述目的

本文总结了人类嗜T细胞病毒相关白血病/淋巴瘤当前的病理生理基础以及过去、现在和未来的治疗选择。

最新发现

已发表了关于同种异体干细胞移植、三氧化二砷和硼替佐米用于该疾病的新研究。

总结

对人类嗜T细胞病毒1型诱导的T细胞白血病/淋巴瘤的分子生物学研究确定了癌蛋白Tax以及核因子κB转录途径激活的关键作用，这为改善T细胞白血病/淋巴瘤的治疗提供了合理方法，并为其他以核因子κB激活为特征的造血系统恶性肿瘤提供了模型。