Morales José M, Dominguez-Gil Beatriz
Renal Transplant Unit, Nephrology Department, Hospital 12 de Octubre, Carretera de Andalucia Km 5,400, 28041 Madrid, Spain.
J Hypertens. 2005 Sep;23(9):1609-16. doi: 10.1097/01.hjh.0000180159.81640.2f.
Cardiovascular disease remains the main cause of death among kidney transplant patients. Cardiovascular risk burden already present at the moment of transplantation is substantially worsened by chronic use of immunosuppressants. On the other hand, chronic allograft nephropathy, a clinical-pathological result of immunological and non-immunological damage of the graft, is the main cause of graft loss in the long-term. Among the non-immunological factors contributing to the development of chronic allograft nephropathy, cardiovascular risk factors also seem to play a role. In the present review, we analyse the impact of the different immunosuppressive medications on cardiovascular risk factors after renal transplantation, including renal function.
心血管疾病仍然是肾移植患者的主要死因。移植时就已存在的心血管风险负担因长期使用免疫抑制剂而显著加重。另一方面，慢性移植肾肾病作为移植物免疫和非免疫损伤的临床病理结果，是长期移植物丢失的主要原因。在导致慢性移植肾肾病发生的非免疫因素中，心血管危险因素似乎也起了作用。在本综述中，我们分析了不同免疫抑制药物对肾移植后心血管危险因素（包括肾功能）的影响。
