Thierry Benjamin, Merhi Yahye, Silver Jim, Tabrizian Maryam
Department of Biomedical Engineering, McGill University, 3775 University Street, Montreal, Quebec H3A 2B4, Canada.
J Biomed Mater Res A. 2005 Dec 1;75(3):556-66. doi: 10.1002/jbm.a.30450.
Membrane-covered devices could help treat disease of the vasculature such as aneurysm, rupture, and fistulas. They are also investigated to reduce embolic complication associated with revascularization of saphenous vein graft. The aim of this study is to design a clinically applicable biodegradable membrane-covered stent based on the natural polysaccharide chitosan, which has been developed. The mechanical properties of the membrane is optimized through blending with polyethylene oxide (70:30% Wt CH:PEO). The membrane was able to sustain the mechanical deformation of the supporting self-expandable metallic stents during its deployment. The membrane was demonstrated to resist physiological transmural pressure (burst pressure resistance >500 mm Hg) and presented a high-water permeation resistance (1 mL/cm(2) min(-1) at 120 mmHg). The CH-PEO membrane showed a good hemocompatibility in an ex vivo assay. Heparin and hyaluronan surface complexation with the membrane further reduced platelet adhesion by 50.1 and 63% (p = 0.05). The ability of the membrane-covered devices to be used as a drug reservoir was investigated using the nitric oxide donor sodium nitroprusside (SNP). SNP-loaded membranes displayed significantly reduced platelet adhesion.
覆膜装置有助于治疗血管疾病，如动脉瘤、破裂和瘘管。它们也被用于研究减少与大隐静脉移植血管再血管化相关的栓塞并发症。本研究的目的是基于已开发的天然多糖壳聚糖设计一种临床适用的可生物降解覆膜支架。通过与聚环氧乙烷（70:30%重量比的壳聚糖:聚环氧乙烷）共混来优化膜的机械性能。该膜能够在其展开过程中承受支撑性自膨胀金属支架的机械变形。该膜被证明能够抵抗生理跨壁压力（爆破压力阻力>500 mmHg），并具有高抗水渗透性（在120 mmHg下为1 mL/cm² min⁻¹）。壳聚糖-聚环氧乙烷膜在体外试验中显示出良好的血液相容性。肝素和透明质酸与该膜的表面络合进一步使血小板粘附减少了50.1%和63%（p = 0.05）。使用一氧化氮供体硝普钠（SNP）研究了覆膜装置作为药物储存库的能力。载有SNP的膜显示血小板粘附显著减少。
