Marine Biochemistry Laboratory, Department of Chemistry, Pukyong National University, Busan, Korea.
Mar Drugs. 2010 Nov 29;8(12):2871-92. doi: 10.3390/md8122871.
Human immunodeficiency virus (HIV) infection causes acquired immune deficiency syndrome (AIDS) and is a global public health issue. Anti-HIV therapy involving chemical drugs has improved the life quality of HIV/AIDS patients. However, emergence of HIV drug resistance, side effects and the necessity for long-term anti-HIV treatment are the main reasons for failure of anti-HIV therapy. Therefore, it is essential to isolate novel anti-HIV therapeutics from natural resources. Recently, a great deal of interest has been expressed regarding marine-derived anti-HIV agents such as phlorotannins, sulfated chitooligosaccharides, sulfated polysaccharides, lectins and bioactive peptides. This contribution presents an overview of anti-HIV therapeutics derived from marine resources and their potential application in HIV therapy.
人类免疫缺陷病毒（HIV）感染会导致获得性免疫缺陷综合征（AIDS），是一个全球性的公共卫生问题。包含化学药物的抗 HIV 疗法提高了 HIV/AIDS 患者的生活质量。然而，HIV 耐药性的出现、药物的副作用以及长期抗 HIV 治疗的必要性是导致抗 HIV 治疗失败的主要原因。因此，从自然资源中分离新型抗 HIV 药物至关重要。最近，人们对海洋来源的抗 HIV 药物产生了浓厚的兴趣，如岩藻依聚糖、硫酸化壳寡糖、硫酸化多糖、凝集素和生物活性肽等。本文综述了海洋资源来源的抗 HIV 治疗药物及其在 HIV 治疗中的应用潜力。
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