反式-5-氨基哌啶基-aegPNA嵌合体：在双链/三链模式下与DNA/RNA结合偏好性的设计、合成及研究

trans-5-aminopipecolyl-aegPNA chimera: design, synthesis, and study of binding preferences with DNA/RNA in duplex/triplex mode.

作者信息

Lonkar Pallavi S, Kumar Vaijayanti A

机构信息

Division of Organic Chemistry (Synthesis), National Chemical Laboratory, Pune 411008, India.

出版信息

J Org Chem. 2005 Aug 19;70(17):6956-9. doi: 10.1021/jo0506884.

DOI:10.1021/jo0506884

Abstract

The design and synthesis of novel chiral PNA monomer based on trans-5-aminopipecolic acid is reported. The trans diequatorial disposition of the 1,4 ring substituents in six-membered 5-aminopipecolic acid derivative could be favorable over trans 1,3 axial-equatorial disposition in 4-aminopipecolic acid of PNA. Studies on the synthesis of trans-4/5-aminopipecolyl PNA-eagPNA chimeras and their binding preferences to DNA/RNA in duplex/triplex modes are described.

摘要

报道了基于反式-5-氨基哌啶酸的新型手性肽核酸单体的设计与合成。六元5-氨基哌啶酸衍生物中1,4环取代基的反式双平伏键排列可能优于肽核酸的4-氨基哌啶酸中的反式1,3轴向-平伏键排列。描述了反式-4/5-氨基哌啶基肽核酸-嗜酸性粒细胞增强蛋白肽核酸嵌合体的合成及其在双链/三链模式下与DNA/RNA的结合偏好研究。

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