Myers Michael C, Witschi Mark A, Larionova Nataliya V, Franck John M, Haynes Russell D, Hara Toshiaki, Grajkowski Andrzej, Appella Daniel H
Department of Chemistry, Northwestern University, Evanston, Illinois 60208, USA.
Org Lett. 2003 Jul 24;5(15):2695-8. doi: 10.1021/ol0348811.
[structure: see text] A strategy to restrict the highly flexible backbone conformation of a peptide nucleic acid (PNA) by incorporation of a cyclopentane ring is proposed. An asymmetric synthesis of cyclopentane-modified PNA is reported, and its binding properties were determined. The cyclopentane ring leads to a significant improvement in the binding properties of the resulting PNA to DNA and RNA.
[结构：见正文] 提出了一种通过并入环戊烷环来限制肽核酸（PNA）高度灵活的主链构象的策略。报道了环戊烷修饰的PNA的不对称合成，并测定了其结合特性。环戊烷环使所得PNA与DNA和RNA的结合特性有显著改善。
