Burge Chandra N, Chang Helena R, Apple Sophia K
Department of Pathology, David Geffen School of Medicine at University of California at Los Angeles, Mail Code: 173216, 10833 Le Conte Avenue, Los Angeles, CA 90095-1732, USA.
Breast. 2006 Apr;15(2):167-72. doi: 10.1016/j.breast.2005.06.004. Epub 2005 Aug 10.
Core biopsies are commonly used in the diagnosis of breast cancer and often are the only sample for providing prognostic and predictive markers prior to neoadjuvant chemotherapy. We retrospectively studied 87 patients with breast cancer to compare the concordance rates for tumor type, grade, estrogen receptor/progesterone receptor (ER/PR), p53 status and Her2/neu by immunohistochemistry (IHC) and fluorescent in situ hybridization (FISH) between core and excisional biopsy specimens. The histologic type of cancer had a 100% concordance rate between core and excisional biopsy specimens. The concordance rate of modified Bloom-Richardson score between core and excisional biopsy specimens was 77%, ER was 95%, PR was 89%, and p53 was 86%. The concordance rate for Her2/neu by IHC was 96% and that for FISH was 100% between the core and excisional biopsy specimens. Although breast cancer may have heterogeneous histological and immunohistochemical findings, our study shows that relatively high concordance rates can be obtained when comparing core and excisional biopsy specimens.
粗针活检常用于乳腺癌的诊断，并且常常是在新辅助化疗前提供预后和预测标志物的唯一样本。我们回顾性研究了87例乳腺癌患者，以比较粗针活检标本和切除活检标本之间在肿瘤类型、分级、雌激素受体/孕激素受体（ER/PR）、p53状态以及通过免疫组织化学（IHC）和荧光原位杂交（FISH）检测的Her2/neu的一致性率。癌的组织学类型在粗针活检标本和切除活检标本之间的一致性率为100%。粗针活检标本和切除活检标本之间改良的Bloom-Richardson评分的一致性率为77%，ER为95%，PR为89%，p53为86%。粗针活检标本和切除活检标本之间通过IHC检测的Her2/neu的一致性率为96%，通过FISH检测的一致性率为100%。尽管乳腺癌可能有不同的组织学和免疫组化表现，但我们的研究表明，比较粗针活检标本和切除活检标本时可获得相对较高的一致性率。
