尼卡斯特林：γ-分泌酶复合物的守门人。

Nicastrin: gatekeeper of the gamma-secretase complex.

作者信息

De Strooper Bart

机构信息

Center for Human Genetics, VIB4 and KULeuven, 3000 Leuven, Belgium.

出版信息

Cell. 2005 Aug 12;122(3):318-20. doi: 10.1016/j.cell.2005.07.021.

DOI:10.1016/j.cell.2005.07.021

PMID:16096051

Abstract

The gamma-secretase intramembrane protease cleaves many type I membrane proteins including amyloid precursor protein and Notch, generating peptide fragments that are important signaling components. In this issue of Cell, Shah et al. (2005) reveal the function of nicastrin, the largest member of the gamma-secretase complex. They show that the nicastrin extracellular domain is essential for recognition of substrate by the gamma-secretase.

摘要

γ-分泌酶跨膜蛋白酶可切割多种I型膜蛋白，包括淀粉样前体蛋白和Notch，产生作为重要信号成分的肽片段。在本期《细胞》杂志中，沙阿等人（2005年）揭示了γ-分泌酶复合物最大成员尼卡斯特林的功能。他们表明，尼卡斯特林细胞外结构域对于γ-分泌酶识别底物至关重要。