沙门氏菌对宿主防御分子的感受器。

Salmonella's sensor for host defense molecules.

作者信息

Hancock Robert E W, McPhee Joseph B

机构信息

Centre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, British Columbia, V6T 1Z4, Canada.

出版信息

Cell. 2005 Aug 12;122(3):320-2. doi: 10.1016/j.cell.2005.07.023.

DOI:10.1016/j.cell.2005.07.023

PMID:16096052

Abstract

The bacterial pathogen Salmonella typhimurium resides within phagosomes in host cells and is able to deflect the host immune response. In this issue of Cell, Bader et al. (2005) decipher an elegant mechanism by which the PhoQ sensor kinase of Salmonella is switched on by host cationic antimicrobial peptides, leading to changes in gene expression that enable Salmonella to combat the host immune response.

摘要

鼠伤寒沙门氏菌这种细菌病原体寄居于宿主细胞的吞噬体中，并且能够规避宿主的免疫反应。在本期《细胞》杂志中，巴德等人（2005年）破解了一种精妙的机制，通过该机制，沙门氏菌的PhoQ传感激酶被宿主阳离子抗菌肽激活，进而导致基因表达发生变化，使沙门氏菌能够对抗宿主的免疫反应。