Nielsen Jonas, Østergaard Morten, Kjaergaard Jesper, Tingleff Jens, Berthelsen Preben G, Nygård Eigil, Larsson Anders
Department of Anesthesia and Intensive Care Medicine, Copenhagen University Hospital Gentofte, Niels Andersens Vej 64, 2900 Hellerup, Denmark.
Intensive Care Med. 2005 Sep;31(9):1189-94. doi: 10.1007/s00134-005-2732-z. Epub 2005 Aug 12.
To assess the impact of the lung recruitment maneuver on circulation following cardiac surgery.
Prospective randomized cross-over study at the Departments of Anesthesia and Thoracic Surgery, Copenhagen University Hospital.
Ten adult undergoing coronary artery bypass surgery.
Patients were randomized to two durations of lung recruitment maneuvers (40 cmH2O airway pressure for 10 s and 20 s or vice versa after 5 min) administered immediately after surgery.
Transesophageal echocardiography (left ventricular short axis view), pulse contour cardiac output, and arterial blood pressure were monitored continuously. Systemic and pulmonary arterial blood gases were sampled before and after each lung recruitment maneuver to calculate the intrapulmonary shunt. Left ventricular end-diastolic areas decreased significantly during both the 10-s and the 20-s lung recruitment maneuvers. Cardiac output was 5.6+/-0.8 l/min at baseline, decreasing by 3.0+/-1.1 l/min and 3.6+/-1.2 l/min during lung recruitment maneuvers of 10 and 20 s, respectively. Shunt decreased from 20+/-5% to 15+/-6% after the first lung recruitment maneuver and from 15+/-6% to 12+/-5% after the second.
Lung recruitment maneuvers markedly reduced cardiac output and left ventricular end-diastolic areas in hemodynamically stable patients following cardiac surgery.
评估心脏手术后肺复张手法对循环系统的影响。
哥本哈根大学医院麻醉科和胸外科进行的前瞻性随机交叉研究。
10名接受冠状动脉搭桥手术的成年人。
患者被随机分为两组,在手术后立即给予两种不同时长的肺复张手法(气道压力40 cmH2O,持续10秒和20秒,或5分钟后互换)。
持续监测经食管超声心动图(左心室短轴视图)、脉搏轮廓心输出量和动脉血压。在每次肺复张手法前后采集体循环和肺动脉血气样本,以计算肺内分流。在10秒和20秒的肺复张手法过程中,左心室舒张末期面积均显著减小。基线时心输出量为5.6±0.8升/分钟,在10秒和20秒的肺复张手法过程中分别下降3.0±1.1升/分钟和3.6±1.2升/分钟。首次肺复张手法后分流从20±5%降至15±6%,第二次后从15±6%降至12±5%。
在心脏手术后血流动力学稳定的患者中,肺复张手法显著降低了心输出量和左心室舒张末期面积。