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半侧卧位下肺复张对腹腔镜手术后患者生理状况的影响:一项随机对照研究。

Physiological benefits of lung recruitment in the semi-lateral position after laparoscopic surgery: a randomized controlled study.

机构信息

Department of Anesthesiology and Pain Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Irwon-ro 81, Gangnam-gu, Seoul, 06351, Korea.

Department of Anesthesiology and Pain Medicine, Seongnam Citizens Medical Center, Seongnam, 13290, Korea.

出版信息

Sci Rep. 2022 Mar 10;12(1):3909. doi: 10.1038/s41598-022-04841-8.

DOI:10.1038/s41598-022-04841-8
PMID:35273175
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8913840/
Abstract

We evaluated the physiological benefits of performing lung recruitment maneuver (LRM) in the semi-lateral position compared in the supine position. Seventy-nine patients undergoing laparoscopic prostatectomy were randomly assigned to either the supine or semi-lateral group according to body position during the LRM. At the end of surgery, LRM (35 cmHO for 20 s) was performed twice in the assigned posture. The primary outcome was the maximal decrease in systolic arterial pressure during LRM. Secondary outcomes were changes in PaO/FiO and the regional lung volume distribution after LRM. The decrease in systolic arterial pressure during the LRM was significantly higher in the supine group than in the semi-lateral group (mean ± standard deviation, [-] 27.6 ± 14.6% vs. [-] 18.6 ± 9.9%, P = 0.001). Improvement in PaO/FiO ratio after the LRM was evident in both groups but was more prominent in the semi-lateral group than in the supine group (median [interquartile range], 39.3% [20.2, 63.6] vs. 18.2% [8.4, 29.2], P = 0.001). Among the horizontal lung divisions, regional lung volume in the most dependent portion (the dorsal division) was significantly increased after the LRM only in the semi-lateral group (P = 0.024). Performing lung recruitment in a semi-lateral position protected against hemodynamic deterioration during the LRM and increased regional lung ventilation in the dependent portion of the lung, leading to an improvement in arterial oxygenation after laparoscopic procedures.Trial registration Clinical Research Information Service ( https://cris.nih.go.kr/ ). Identifier: KCT0003756.

摘要

我们评估了在半侧卧位与仰卧位行肺复张手法(LRM)的生理获益。根据 LRM 期间的体位,79 例行腹腔镜前列腺切除术的患者被随机分配至仰卧位或半侧卧位组。手术结束时,在指定体位下进行两次 LRM(35cmH2O 持续 20s)。主要结局为 LRM 期间收缩压的最大下降幅度。次要结局为 LRM 后 PaO/FiO 和区域性肺容积分布的变化。LRM 期间收缩压的下降幅度在仰卧位组显著高于半侧卧位组(均数±标准差,[-]27.6±14.6%比[-]18.6±9.9%,P=0.001)。两组患者的 PaO/FiO 比值在 LRM 后均明显改善,但半侧卧位组的改善更显著(中位数[四分位数间距],39.3%[20.2,63.6]比 18.2%[8.4,29.2],P=0.001)。在水平肺分区中,仅在半侧卧位组,LRM 后最依赖部分(背部分区)的区域性肺容积显著增加(P=0.024)。在半侧卧位行肺复张可防止 LRM 期间的血液动力学恶化,并增加肺依赖区的区域性肺通气,从而改善腹腔镜手术后的动脉氧合。

试验注册 临床研究信息服务(https://cris.nih.go.kr/)。标识符:KCT0003756。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/311a/8913840/32f85e538f48/41598_2022_4841_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/311a/8913840/44338718df30/41598_2022_4841_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/311a/8913840/d71d183927e0/41598_2022_4841_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/311a/8913840/32f85e538f48/41598_2022_4841_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/311a/8913840/44338718df30/41598_2022_4841_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/311a/8913840/d71d183927e0/41598_2022_4841_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/311a/8913840/32f85e538f48/41598_2022_4841_Fig3_HTML.jpg

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PLoS One. 2019 May 29;14(5):e0217405. doi: 10.1371/journal.pone.0217405. eCollection 2019.
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