Takeuchi Hiroshi, Saitoh Shigeyuki, Takagi Satoru, Ohnishi Hirofumi, Ohhata Junichi, Isobe Takeshi, Shimamoto Kazuaki
Second Department of Internal Medicine, Sapporo Medical University School of Medicine, South-1, West-16, Chuo-ku, Sapporo 060-8543, Japan.
Hypertens Res. 2005 Mar;28(3):203-8. doi: 10.1291/hypres.28.203.
Results of a 6-year follow-up study were used to determine whether the concept of and the criteria for metabolic syndrome as defined by the National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATP III) can be applied to Japanese men for prediction of the occurrence of cardiac disease. The subjects were 808 men who underwent mass health check-ups in 1993 and who were not on medication for hypertension, diabetes or hyperlipidemia. Individuals who had hypertriglyceridemia, hypo-high density lipoprotein (HDL) cholesterolemia, high blood pressure, and/or high fasting plasma glucose levels were identified on the basis of the NCEP-ATP III criteria. Not in conformity with the NCEP-ATP Ill, however, a cut-off value of 85 cm was used for waist girth as an indicator of abdominal obesity. The subjects who had 3 or more risk factors were judged as having metabolic syndrome. The proportion of subjects having metabolic syndrome was 25.3%. In the 6-year follow-up study, cardiac disease occurred in 11.7% of the subjects in the metabolic syndrome group and in 6.7% of the subjects in the non-metabolic syndrome group. Results of regression analysis using Cox's proportional hazards model showed that subjects in the metabolic syndrome group had a 2.2-times greater risk of developing cardiac disease than did subjects in the non-metabolic syndrome group. The concept of metabolic syndrome as defined in the NCEP-ATP III was therefore considered to be useful for predicting the occurrence of cardiac disease in Japanese men.
一项为期6年的随访研究结果被用于确定美国国家胆固醇教育计划成人治疗专家组第三次报告（NCEP-ATP III）所定义的代谢综合征概念及标准是否可应用于日本男性，以预测心脏病的发生。研究对象为808名于1993年接受大规模健康检查且未服用治疗高血压、糖尿病或高脂血症药物的男性。根据NCEP-ATP III标准确定患有高甘油三酯血症、低高密度脂蛋白（HDL）胆固醇血症、高血压和/或高空腹血糖水平的个体。然而，与NCEP-ATP III不同的是，腰围的截断值采用85厘米作为腹部肥胖的指标。有3种或更多危险因素的受试者被判定为患有代谢综合征。患有代谢综合征的受试者比例为25.3%。在6年的随访研究中，代谢综合征组11.7%的受试者发生了心脏病，非代谢综合征组为6.7%。使用Cox比例风险模型进行回归分析的结果显示，代谢综合征组的受试者患心脏病的风险是非代谢综合征组受试者的2.2倍。因此，NCEP-ATP III中定义的代谢综合征概念被认为有助于预测日本男性心脏病的发生。
