Miller A, Furlong D, Burrows B A, Slingerland D W
Medical Service, Boston DVA Medical Center, MA 02130.
Am J Hematol. 1992 Jul;40(3):163-6. doi: 10.1002/ajh.2830400302.
In many patients with low serum levels of vitamin B12, the absorption of the free vitamin has been normal. The present study, using a total body counter 57CoB12 absorption method that clearly separated those with intrinsic factor deficiency from controls, found that of 94 patients with low B12 levels and intact stomachs in whom the absorption of free and bound B12 was determined, 44 (47%) had normal absorption of both. However, 20 of the 94 (21%) with normal absorption of free B12 had low absorption of bound B12. The remainder (32%) had low absorption of both free and bound B12. All patients with high serum gastrin levels had low bound B12 absorption, but so did 21% of those patients with normal serum gastrin levels.
在许多血清维生素B12水平较低的患者中，游离维生素的吸收一直是正常的。本研究采用全身计数器57CoB12吸收法，该方法能明确区分内因子缺乏者与对照组，发现在94例B12水平低且胃部完好的患者中，测定了游离和结合型B12的吸收情况，其中44例（47%）两者吸收均正常。然而，94例中20例（21%）游离B12吸收正常，但结合型B12吸收较低。其余患者（32%）游离和结合型B12吸收均较低。所有血清胃泌素水平高的患者结合型B12吸收均较低，但血清胃泌素水平正常的患者中也有21%是如此。
