Dawson D W, Sawers A H, Sharma R K
Br Med J (Clin Res Ed). 1984 Mar 3;288(6418):675-8. doi: 10.1136/bmj.288.6418.675.
Patients with subnormal serum vitamin B12 concentrations were tested for absorption of protein bound vitamin B12 and compared with controls. Absorption of the protein bound vitamin appeared to decrease with increasing age in healthy subjects. Differences between the result of this test and the result of the Schilling test in patients who had undergone gastric surgery were confirmed; such differences were also seen in some patients who had iron deficiency anaemia, an excessive alcohol intake, or folate deficiency. Defective absorption was also found in six patients with an adequate dietary intake of vitamin B12, normal Schilling test results, low serum vitamin concentrations, and tissue changes responding to treatment with vitamin B12. Malabsorption of the vitamin from protein bound sources, which is not detected by the Schilling test, may produce vitamin B12 deficiency of clinical importance.
对血清维生素B12浓度低于正常水平的患者进行了蛋白质结合型维生素B12吸收测试，并与对照组进行比较。在健康受试者中，蛋白质结合型维生素的吸收似乎随年龄增长而降低。已证实接受过胃部手术的患者该测试结果与希林试验结果存在差异；在一些患有缺铁性贫血、过量饮酒或叶酸缺乏的患者中也观察到了这种差异。在6名维生素B12饮食摄入量充足、希林试验结果正常、血清维生素浓度低且组织变化对维生素B12治疗有反应的患者中也发现了吸收缺陷。希林试验未检测到的蛋白质结合来源维生素吸收不良可能会导致具有临床重要性的维生素B12缺乏。
