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DNA甲基转移酶与真核生物DNA修饰的结构-功能特异性

DNA methyltransferases and structural-functional specificity of eukaryotic DNA modification.

作者信息

Buryanov Ya I, Shevchuk T V

机构信息

Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Pushchino Branch, Russian Academy of Sciences, Pushchino, Moscow Region, 142290, Russia.

出版信息

Biochemistry (Mosc). 2005 Jul;70(7):730-42. doi: 10.1007/s10541-005-0178-0.

DOI:10.1007/s10541-005-0178-0
PMID:16097936
Abstract

Properties of the main families of mammalian, plant, and fungal DNA methyltransferases are considered. Structural-functional specificity of eukaryotic genome sequences methylated by DNA methyltransferases is characterized. The total methylation of cytosine in DNA sequences is described, as well as its relation with RNA interference. Mechanisms of regulation of expression and modulation of DNA methyltransferase activity in the eukaryotic cell are discussed.

摘要

本文探讨了哺乳动物、植物和真菌DNA甲基转移酶主要家族的特性。对DNA甲基转移酶甲基化的真核基因组序列的结构功能特异性进行了表征。描述了DNA序列中胞嘧啶的整体甲基化情况及其与RNA干扰的关系。讨论了真核细胞中DNA甲基转移酶活性的表达调控机制和调节机制。

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