Bonnet Dominique
Haematopoietic Stem Cell Laboratory, Cancer Research UK, London Research Institute, London, UK.
Br J Haematol. 2005 Aug;130(4):469-79. doi: 10.1111/j.1365-2141.2005.05596.x.
The blood-related cancer leukaemias were the first diseases where human cancer stem cells, or leukaemic stem cells (LSC), were isolated. The haematopoietic system is one of the best tissues for investigating cancer stem cells, because the developmental hierarchy of normal blood formation is well defined. Leukaemias can now be viewed as aberrant haematopoietic processes initiated by rare LSC that have maintained or reacquired the capacity for indefinite proliferation through accumulated mutations and/or epigenetic changes. Yet, despite their critical importance, much remains to be learned about the developmental origin of LSC and the mechanisms responsible for their emergence in the course of the disease. This report will review our current knowledge on normal and LSC development and examine the impact of these discoveries may have clinically and in our understanding of the leukaemogenic process.
血癌白血病是最早分离出人类癌症干细胞即白血病干细胞（LSC）的疾病。造血系统是研究癌症干细胞的最佳组织之一，因为正常血液形成的发育层次已明确界定。现在可以将白血病视为由罕见的LSC引发的异常造血过程，这些LSC通过累积突变和/或表观遗传变化维持或重新获得了无限增殖的能力。然而，尽管它们至关重要，但关于LSC的发育起源以及疾病过程中其出现的机制仍有许多有待了解。本报告将回顾我们目前对正常和LSC发育的认识，并探讨这些发现可能在临床上以及对我们理解白血病发生过程产生的影响。
