Stubbs Matthew C, Armstrong Scott A
Division of Hematology/Oncology, Children's Hospital Boston, Department of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, USA.
Clin Cancer Res. 2007 Jun 15;13(12):3439-42. doi: 10.1158/1078-0432.CCR-06-3090.
Acute myelogenous leukemias, and perhaps many other cancers, are maintained by a population of cancer stem cells that can regenerate themselves as well as give rise to more differentiated and less proliferative cells that constitute the bulk of the disease. Recent discoveries have shed light on both the nature of leukemia stem cells (LSC) and their cells of origin. Here, we review which hematopoietic cells could give rise to LSC, and the phenotype of fully developed LSC. The perturbed developmental pathways and cellular context of LSC development have implications for the development of new therapeutic approaches.
急性髓性白血病，或许还有许多其他癌症，是由一群癌症干细胞维持的，这些干细胞既能自我更新，又能产生更多分化程度更高、增殖能力更低的细胞，而这些细胞构成了疾病的主体。最近的发现揭示了白血病干细胞（LSC）的本质及其起源细胞。在这里，我们综述了哪些造血细胞可以产生LSC，以及完全发育的LSC的表型。LSC发育过程中受到干扰的发育途径和细胞环境对新治疗方法的开发具有重要意义。
