Bear M F
The Picower Center for Learning and Memory, Howard Hughes Medical Institute and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, 02139, USA.
Genes Brain Behav. 2005 Aug;4(6):393-8. doi: 10.1111/j.1601-183X.2005.00135.x.
Evidence is reviewed that the consequences of group 1 metabotropic glutamate receptor (Gp1 mGluR) activation are exaggerated in the absence of the fragile X mental retardation protein, likely reflecting altered dendritic protein synthesis. Abnormal mGluR signaling could be responsible for remarkably diverse psychiatric and neurological symptoms in fragile X syndrome, including delayed cognitive development, seizures, anxiety, movement disorders and obesity.
有证据表明，在缺乏脆性X智力低下蛋白的情况下，第1组代谢型谷氨酸受体（Gp1 mGluR）激活的后果会被放大，这可能反映了树突状蛋白合成的改变。异常的mGluR信号传导可能是脆性X综合征中多种精神和神经症状的原因，包括认知发育迟缓、癫痫、焦虑、运动障碍和肥胖。
