Fuks Zvi, Kolesnick Richard
Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA.
Cancer Cell. 2005 Aug;8(2):89-91. doi: 10.1016/j.ccr.2005.07.014.
Recent research has shed new light on the critical role of tissue microvasculature in regulating the tumor response to radiation and drugs. In this issue of Cancer Cell, Moeller et al.(2005) demonstrate that HIF-1 activation during the course of fractionated radiotherapy initiates pleiotropic adaptive responses in both tumor cells and the microvascular network, radiosensitizing tumor cells but concomitantly conferring tumor radioresistance due to protection of the microvascular endothelium. HIF-1 thus serves as a legitimate target for differential modulation of tissue response to radiation.
近期研究为组织微血管在调节肿瘤对放疗和药物的反应中的关键作用带来了新的认识。在本期《癌细胞》杂志中，莫勒等人（2005年）证明，在分次放疗过程中HIF-1的激活会在肿瘤细胞和微血管网络中引发多效性适应性反应，使肿瘤细胞对放疗敏感，但同时由于对微血管内皮的保护而赋予肿瘤放射抗性。因此，HIF-1可作为对组织放疗反应进行差异调节的合理靶点。
