Ruf Jean, Carayon Pierre
INSERM Unit U555, Faculté de Médecine Timone, Université de la Méditerranée, Marseille, France.
Arch Biochem Biophys. 2006 Jan 15;445(2):269-77. doi: 10.1016/j.abb.2005.06.023. Epub 2005 Jul 27.
Thyroperoxidase (TPO) is the enzyme involved in thyroid hormone synthesis. Although many studies have been carried out on TPO since it was first identified as being the thyroid microsomal antigen involved in autoimmune thyroid disease, previous authors have focused more on the immunological than on the biochemical aspects of TPO during the last few years. Here, we review the latest contributions in the field of TPO research and provide a large reference list of original publications. Given this promising background, scientists and clinicians will certainly continue in the future to investigate the mechanisms whereby TPO contributes to hormone synthesis and constitutes an important autoantigen involved in autoimmune thyroid disease, and the circumstances under which the normal physiological function of this enzyme takes on a pathological role.
甲状腺过氧化物酶（TPO）是参与甲状腺激素合成的酶。自从TPO首次被确定为参与自身免疫性甲状腺疾病的甲状腺微粒体抗原以来，虽然已经对其进行了许多研究，但在过去几年中，先前的作者更多地关注TPO的免疫学方面，而非生化方面。在此，我们回顾了TPO研究领域的最新贡献，并提供了大量原始出版物的参考文献列表。鉴于这一前景广阔的背景，科学家和临床医生未来肯定会继续研究TPO促进激素合成并构成参与自身免疫性甲状腺疾病的重要自身抗原的机制，以及该酶的正常生理功能在何种情况下发挥病理作用。
